Actinomycin

Within months, the team had confirmed that X-rays and actinomycin D were remarkably synergistic, each multiplying the toxic effect of the other. ❋ Siddhartha Mukherjee (2010)

Others, such as nitrogen mustard or actinomycin D, came from serendipitous sources, such as mustard gas or soil bacteria, found accidentally to kill cancer cells. ❋ Siddhartha Mukherjee (2010)

Farber found that actinomycin D, administered intravenously, potently inhibited the growth of these lung metastases, often producing remissions that lasted months. ❋ Siddhartha Mukherjee (2010)

In the summer of 1954, Farber persuaded Waksman to send him a number of antibiotics, including actinomycin D, to repurpose them as antitumor agents by testing the drugs on a series of mouse tumors. ❋ Siddhartha Mukherjee (2010)

An enormous molecule shaped like an ancient Greek statue, with a small, headless torso and two extended wings, actinomycin D was later found to work by binding and damaging DNA. ❋ Siddhartha Mukherjee (2010)

He has isolated, together with his students and associates, a number of new antibiotics, including actinomycin (1940), clavacin, streptothricin (1942), streptomycin (1943), grisein ❋ Unknown (1964)

Cells were harvested at the indicated time points (hours after addition of actinomycin or vehicle or transfection with agRNA). ❋ Xuan Yue (2010)

After 2 d, actinomycin D (act D, 1 μg ml − 1) or vehicle was added to the medium. ❋ Xuan Yue (2010)

(Pol I) are polyadenylated and accumulate markedly after treatment with low concentrations of actinomycin D (ActD), which blocks the synthesis of full-length rRNA. ❋ Natalia Shcherbik (2010)

Overexpression of L11 or actinomycin D-induced ribosomal stress increases this L11-MDM2 interaction and subsequent p53 stabilization ❋ Unknown (2009)