So, there's a class of drugs called the adamantane drugs, what is called rimantadine and amantadine. ❋ Unknown (2006)
The stockpile has 40 million treatment courses of Tamiflu, 10 million courses of Relenza and nearly three million courses of an adamantane. ❋ Unknown (2009)
My main interests were natural compounds, from adamantane and aialoids to rifamycins and boromycin. ❋ Unknown (1976)
The proportion of adamantane-resistant A (H3N2) viruses increased from 74% in 2005-2007, to ❋ Unknown (2009)
The presence or absence of S31N mutations in M2 protein was the major determinant of adamantane resistance. ❋ Unknown (2009)
They found that about one-third of those samples carried mutations enabling the virus strains to resist the effects of adamantane drugs. ❋ Unknown (2009)
Similar issues confront clinicians treating patients hospitalized with severe lower respiratory tract disease due to novel swine-origin influenza A (H1N1) virus infection (currently resistant to adamantane antivirals) ❋ Nicholas J. White Et Al. (2009)
Over time, widespread use of this relatively older class of drugs has put significant evolutionary pressure on influenza, giving viruses with this mutation a selective advantage, leading to increasing rates of adamantane resistance in recent years. ❋ Unknown (2009)
The recommended alternative is combining an adamantane (preferably rimantidine) with oseltamivir, which provides coverage for either strain and may enhance efficacy while reducing the likelihood of resistance. ❋ Unknown (2009)
Swine flu, however, has a single mutation (S31N) that makes it resistant to adamantane drugs. ❋ Unknown (2009)
The oseltamivir flu / A picture was reversed for the older adamantane antivirals (which work by a different mechanism). ❋ Unknown (2009)
This is actually a relatively common mutation found in flu viruses in general and the main source of all flu adamantane resistance. ❋ Unknown (2009)
Currently circulating 2009 H1N1 influenza viruses are sensitive to the neuraminidase inhibitor antiviral medications oseltamivir and zanamivir, but are resistant to the adamantane antiviral medications, amantadine and rimantadine. ❋ Unknown (2009)
The currently circulating swine-origin influenza A (H1N1) virus is sensitive to the neuraminidase inhibitor antiviral medications zanamivir and oseltamivir, but is resistant to the adamantane antiviral medications, amantadine and rimantadine. ❋ Unknown (2009)
The oseltamivir-resistant A (H1N1) or adamantane-resistant A (H3N2) viruses and the sensitive variants produced similar clinical symptoms, the report indicates. ❋ Unknown (2009)
Consequently, 30 percent of the avian flu samples recently analyzed by the study authors proved resistant to the adamantane drugs. ❋ Unknown (2009)
No flu / A virus was simultaneously resistant to oseltamivir and an adamantane antiviral. ❋ Unknown (2009)
Nick Anthis has a very nice (and very readable!) overview of why flu viruses (including the new A / H1N1 strain) are resistant to adamantane ❋ Unknown (2009)
