Allosteric

Under the agreement, Addex will regain rights to intellectual property and know-how and can pursue the program independently. www.addexpharma.com discovers and develops an emerging class of small molecule drugs, called allosteric modulators, which have the potential to be more specific and confer significant therapeutic advantages over conventional "orthosteric" small molecule or biological drugs. ❋ Unknown (2011)

In contrast to some of its rivals, Addex has a relatively wide portfolio of new products and a novel technology platform known as allosteric modulation, factors which analysts say make it a potential star of the Swiss biotech sector. ❋ Unknown (2009)

The researchers have discovered that apamin binds away from the channel pore, and causes the shape of the channel to change through an 'allosteric' mechanism, resulting in block. ❋ Unknown (2010)

As an essential feature, interactions among the components of a system have effects (technically 'allosteric' effects) that help organize and coordinate its processes, allowing the self-replication to proceed. ❋ Unknown (2010)

From these measurements we calculated all of the equilibrium constants of the "allosteric" cycle as follows: diliganded gating, unliganded gating, dissociation from the C (losed) conformation, and dissociation from the O (pen) conformation. ❋ P. A. Bafna (2009)

Scientists already know that a family of 'allosteric' drugs can switch off this enzyme but until now no-one knew how they worked. ❋ Unknown (2009)

Most genetic control mechanisms are based on an "allosteric" molecule that both senses the problem and acts in response to the information. ❋ Unknown (2008)

Paired enzymes are unrelated enzymes that influence metabolic cycles by the same allosteric effectors only in opposite ways at branch points. ❋ Unknown (2009)

Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes. ❋ Unknown (2010)

Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. ❋ Unknown (2010)

The TIBS lecture; the nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels. ❋ T.S. Wiley (2010)

Explanatorily relevant principles for the physics of macromolecules include weak interactions, hydrogen bonding, hydrophobic bonding, allosteric transformations, lock-key fit, or the idea that structure determines function. ❋ Brigandt, Ingo (2008)

The modular logic of signaling proteins: building allosteric switches from simple binding domains. ❋ Michael J. Behe (2007)

Reprogramming control of an allosteric signaling switch through modular recombination. ❋ Michael J. Behe (2007)