Aminosalicylic

In the 1940s, then in Göteborg, Sweden, he discovered para-aminosalicylic acid (PAS), which together with streptomycin, discovered by Waksman, provided the first effective drug treatment for tuberculosis. ❋ Unknown (2001)

But in 1939 it was still very much the case: the discovery of the chemotherapeutic agents, rifampin, para-aminosalicylic acid, isoniazid and especially streptomycin, still lay far beyond a distant horizon. ❋ MacLean, Alistair (1984)

Others at risk of developing a B12 deficiency include heavy drinkers (alcohol diminishes B12 absorption), those who have had stomach surgery for weight loss or ulcers, and people who take aminosalicylic acid (for inflammatory bowel disease or tuberculosis) or the diabetes drug metformin (sold as Glucophage and other brands). ❋ Unknown (2011)

But when streptomycin was combined with PAS (para-aminosalicylic acid) or, better, with the more potent isoniazid in Wallace's UK trials, resistance was largely prevented. ❋ Unknown (2010)

This was a major breakthrough, and combinations of drugs (streptomycin with isoniazid or para-aminosalicylic (PAS) acid given for between one and two years) became the standard regimen in developed countries. ❋ Unknown (2010)

Rand L, Green JA, Saraiva L, Friedland JS, Elkington PT (2009) Matrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade. ❋ Malathesha Ganachari Et Al. (2010)

Isoniazid, aminosalicylic acid, and streptomycin have also been used in multiple drug regimens. ❋ Unknown (2010)

Para-aminosalicylic acid or PAS is one of the drugs most hated by MDR patients. ❋ Unknown (2009)

Crofton and his team then showed that the development of resistance could be delayed by combining streptomycin with another new antibiotic, para-aminosalicylic acid, commonly known as PAS.