It has an anti-infectious action brought about by internal disinfection, but is, in this respect, in contrast to the anti-bacterial disinfectant treatment methods which, for example, can be carried out in laboratory experiments with the aid of the R. Pfeiffer's bacteriolysin; because its activity is only detoxication, we call it antitoxic. ❋ Unknown (1967)
The term "antitoxic" signifies that serum has the power of neutralizing the action of the toxin, as is shown by mixing them together outside the body and then injecting them into an animal. ❋ Various (N/A)
The detoxicating, or as it is also called, the antitoxic serum therapy, is, on the other hand, humoral therapy. ❋ Unknown (1967)
Serum therapy in the form in which it finds application in the treatment of diphtheria patients is an antitoxic or detoxicating curative method. ❋ Unknown (1967)
An attempt has been made to make a comparison between the method of action of the antitoxic serum albumin on the poison molecules with other compensating and inactivating processes. ❋ Unknown (1967)
In addition, a certain time must elapse from the injection of the serum until its antitoxic and healing activity in the affected parts of the body can develop. ❋ Unknown (1967)
I doubt whether it will ever be possible to establish artificially the antitoxic principle of serum therapy in diphtheria, without the aid of vital organization and secretion faculties. ❋ Unknown (1967)
In the years 1881-1883 he carried out important investigations on the action of iodoform, stating that it does not kill microbes but may neutralize the poisons given off by them, thus being antitoxic. ❋ Unknown (1967)
I began then to speak of "neutralization", but right from the start I secured myself against the opinion that the antitoxic and the toxic protein combine in a way which resembles the formation of salts from acid and alkali. ❋ Unknown (1967)
I imagine, in fact, that, as regards chemical analysis, the antitoxic and the toxic protein stay exactly the same after detoxication as before; what changes is simply the activated condition; in the same way as the conductors of positive and negative electricity, before and after compensation of their active conditions, remain the same substances in terms of chemical analysis. ❋ Unknown (1967)
With this example of antitoxic diphtheria therapy, I have attempted to enumerate for you the chief characteristics of serum therapy as a novum in therapeutics and as a progressive step in medicine. ❋ Unknown (1967)
For this reason, these bodies were called antitoxins and the immunity so produced was called antitoxic immunity. ❋ Unknown (1967)
He also showed that the toxin-antitoxin reaction is, as chemical reactions are, accelerated by heat and retarded by cold and that the content of antitoxin in antitoxic sera varied so much for various reasons that it was necessary to establish a standard by which their antitoxin content could be exactly measured. ❋ Unknown (1967)
However this may be, no one doubts any more of the existence of a humoral therapy since antitoxic diphtheria therapy has found an assured place for itself in medicine. ❋ Unknown (1967)
The body-fluids of animals immunized against other pathogens did not present those antitoxic properties, but, nevertheless, the serums did have an energetic action on the infection in question. ❋ Unknown (1967)
The antitoxic property is developed in a susceptible animal by successive and gradually increasing doses of the toxin. ❋ Various (N/A)
Immunity against toxins also became a subject of investigation, and the result was the discovery of the antitoxic action of the serum of animals immunized against tetanus toxin by E. Behring and ❋ Various (N/A)
As a rule it has no action on the corresponding toxin, _i. e._ is not antitoxic. ❋ Various (N/A)
The antitoxic serum when injected previously to the toxin also confers immunity (passive) against it; when injected after the toxin it has within certain limits a curative action, though in this case its dose requires to be large. ❋ Various (N/A)
The injections are made subcutaneously and afterwards intravenously; and, while the dose must be gradually increased, care must be taken that this is not done too quickly, otherwise the antitoxic power of the serum may fall and the health of the animal suffer. ❋ Various (N/A)
