As far as we know, one type of HIV medications is directly imported from U.S.A. to Thailand and the other type of HIV medications is from under license companies in Thailand (for example, Reyataz atazanavir medication, GOP-VIR medication, etc). ❋ Unknown (2009)
Mylan will make available its second-line antiretroviral treatments -- atazanavir, ritonavir, tenofovir and lamivudine. ❋ Unknown (2009)
During the postpartum period, atazanavir concentrations may be increased; therefore, while no dose adjustment is necessary, patients should be monitored for adverse events for two months after delivery.
REYATAZ should be used during pregnancy only if the benefit outweighs the risk and HIV-1 strains are susceptible to atazanavir.
"This labeling update is important news for both healthcare providers and HIV-positive women of child-bearing age in that it provides guidance for the use of REYATAZ, as part of combination therapy, during pregnancy and postpartum," said Dr. Awny Farajallah, MD, FACP, executive director, atazanavir development lead, Bristol-Myers Squibb.
Ritonavir-boosted atazanavir slightly reduced the exposure to telaprevir.
Alternative antiretroviral therapy may be considered if jaundice or scleral icterus present cosmetic concerns. ® atazanavir sulfate with caution in patients with hepatic impairment because atazanavir concentrations may be increased.
Telaprevir slightly increased the exposure to ritonavir-boosted atazanavir.
There was no association between atazanavir and overall birth defects observed in the APR.
As of January 2010, the Antiretroviral Pregnancy Registry (APR) has received prospective reports of 635 exposures to atazanavir-containing regimens (425 exposed in the first trimester and 160 and 50 exposed in second and third trimester, respectively).
A HIV regimen that includes ritonavir-boosted atazanavir is being evaluated in an ongoing Phase 2 study of telaprevir-based therapy in people infected with both hepatitis C and HIV.
Reyataz-based regimen (ritonavir-boosted atazanavir, tenofovir disoproxil fumarate and emtricitabine or lamivudine): TVR was dosed at 750 mg, every 8 hours (q8h).
Available human and animal data suggest that atazanavir does not increase the risk of major birth defects overall compared to the background rate.
All infants, including neonates exposed to REYATAZ ® atazanavir sulfate in-utero, should be monitored for the development of severe hyperbilirubinemia during the first few days of life.
The second phase III trial, Study 103, pits Quad against ritonavir-boosted Reyataz atazanavir and Truvada.
Coadministration with the following is not recommended: nevirapine or salmeterol; other protease inhibitors, fluticasone propionate, or voriconazole when REYATAZ ® atazanavir sulfate is given with ritonavir; buprenorphine or bosentan when REYATAZ is given without ritonavir; proton-pump inhibitors or efavirenz in treatment-experienced patients; and colchicine in patients with renal or hepatic impairment.
The ritonavir-boosted protease inhibitors studied were lopinavir, atazanavir, darunavir and fosamprenavir; the NNRTI was efavirenz and the NRTI was tenofovir.
They also recommend Truvada with either of two protease inhibitors atazanavir or darunavir, and with the integration inhibitor raltegravir. ❋ Unknown (2010)
The risk of myopathy during treatment with CRESTOR may be increased with concurrent administration of some other lipid-lowering therapies (fibrates or niacin), gemfibrozil, cyclosporine, lopinavir/ritonavir, or atazanavir/ritonavir. ❋ Unknown (2010)
The Average Wholesale Price (AWP) for Reyataz (atazanavir) stands at $13,046 per-year. ❋ Unknown (2010)
