Beamline

One of the resulting delicate but durable artworks she has produced uses iron filings to reflect how 'iron' is the connection between a variety of beamline research projects conducted at the facility. ❋ Thatsnews (2008)

The LRL-CAT upgrade included an automation component that allows unattended operation of the beamline for extended periods.

Utilizing the team and beamline at Argonne to develop potential medicines to treat diseases like Alzheimer's is a great example of technology and the human mind coming together.

The beamline helps researchers determine if the molecule (the key) can unlock the protein disease target (the lock) and therefore change its behavior.

The process is iterative, initially using beamline data to design new potential medicines with enhanced properties, which are in turn introduced into protein crystals and then re-analyzed.

Lilly chemists, structural biologists, and the staff at the LRL-CAT beamline facility work together to create molecules, prepare crystals and analyze how the molecules bind to the proteins.

Lilly scientists utilized beamline data to help design our beta-secretase inhibitor which is currently in Phase I clinical testing to determine its potential as a treatment for Alzheimer's disease.

The data produced by the beamline and interpreted by LRL scientists provide valuable information on the interactions between potential new medicines and human disease protein targets.

The LRL-CAT beamline utilizes x-rays to determine if and how the molecule was able to "unlock" the protein, usually within minutes of acquisition.

A simple way to think about the work Lilly scientists are conducting at its beamline facility is to view the disease protein they are studying as the "lock" and the molecule as the "key."

An X-ray beamline at the European Synchrotron Radiation Facility ESRF in France will, hopefully, unlock some of its secrets. ❋ Wired UK (2011)

The Lilly Research Laboratories Collaborative Access Team LRL-CAT beamline is a sophisticated x-ray analytical facility that produces detailed, atom-by-atom pictures of protein crystals.

Once this process is complete, the crystals are sent to the LRL-CAT beamline facility via overnight delivery for analysis.

We thank the beamline staff at EMBL (Hamburg, Germany) for their kind help with the data collection. ❋ Vibha Gupta Et Al. (2010)

They did that at NSLS beamline X1B using resonant soft x-ray scattering, a technique that allows researchers to selectively probe the holes. ❋ Unknown (2010)

This is a simplified sketch of the experiment at the Advanced Light Source's femtosecond spectroscopy beamline. ❋ PhysOrg Team (2010)

Using the ALS's femtosecond (quadrillionth of a second) spectroscopy beamline 6.0.2, ❋ PhysOrg Team (2010)

DIFFABS beamline at SOLEIL, in collaboration with doctors at the Necker Hospital, have carried out for the first time the characterization of a Randall plaque positioned on its renal papilla. ❋ Unknown (2010)