Benzodiazepine Wiki - What is the benzodiazepine?
Benzodiazepines (BZD, BDZ, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann–La Roche, which, since 1963, has also marketed the benzodiazepine diazepam (Valium). In 1977 benzodiazepines were globally the most prescribed medications. They are in the family of drugs commonly known as minor tranquilizers.Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation. These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. Benzodiazepines are categorized as either short-, intermediate-, or long-acting. Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia; longer-acting benzodiazepines are recommended for the treatment of anxiety.Benzodiazepines are generally viewed as safe and effective for short-term use, although cognitive impairment and paradoxical effects such as aggression or behavioral disinhibition occasionally occur. A minority of people can have paradoxical reactions such as worsened agitation or panic. Benzodiazepines are also associated with increased risk of suicide. Long-term use is controversial because of concerns about decreasing effectiveness, physical dependence, withdrawal, and an increased risk of dementia. Stopping benzodiazepines often leads to improved physical and mental health. The elderly are at an increased risk of both short- and long-term adverse effects, and as a result, all benzodiazepines are listed in the Beers List of inappropriate medications for older adults. There is controversy concerning the safety of benzodiazepines in pregnancy. While they are not major teratogens, uncertainty remains as to whether they cause cleft palate in a small number of babies and whether neurobehavioural effects occur as a result of prenatal exposure; they are known to cause withdrawal symptoms in the newborn. Benzodiazepines can be taken in overdoses and can cause dangerous deep unconsciousness. However, they are less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken. When combined with other central nervous system (CNS) depressants such as alcoholic drinks and opioids, the potential for toxicity and fatal overdose increases. Benzodiazepines are commonly misused and taken in combination with other drugs of abuse..
What does the word benzodiazepine mean? Find synonyms, antonyms and the meaning of the word benzodiazepine in our free online dictionary! Find words starting with benzodiazepine and anagrams of benzodiazepine.
Definitions of "benzodiazepine"
- Any of a group of chemical compounds with a common molecular structure and similar pharmacological effects, used as antianxiety agents, muscle relaxants, sedatives, hypnotics, and sometimes as anticonvulsants. noun
- Any of a class of psychoactive drugs, structured upon diazepine, used in the treatment of anxiety, insomnia and other related disorders. noun
- any of several similar lipophilic amines used as tranquilizers or sedatives or hypnotics or muscle relaxants; chronic use can lead to dependency noun
The word "benzodiazepine" in example sentences
Valium, in this patient, we will appreciate how to want term benzodiazepine drugs feeding documents.. [The Clog]
The most common sleep-aid drugs, called benzodiazepine receptor agonists, alter the activity of gamma-aminobutyric acid GABA, a neurotransmitter that is thought to facilitate sleep.. [Dawn of A New Sleep Drug?]
When you are talking about pain pill -- or pain medications like Demerol -- and the Xanax falls into what is known as a benzodiazepine, big name, but a different class of drugs.. [CNN Transcript Jul 9, 2009]
This is a drug called benzodiazepine.2 After a few weeks, he went back on the benzodiazepine, but now it was too late; it no longer stopped him from having attacks.. [The American Radiohead]
A: Lorazepam Ativan is an anti-anxiety agent called a benzodiazepine.. [The Seattle Times]
Researchers from Switzerland and the United States found that so-called benzodiazepine drugs, such as Ativan, Xanax and Valium, exert a calming effect by boosting action of a neurotransmitter called gamma-aminobutyric acid (GABA) in the same way as addictive drugs like opioids and cannabinoids.. [Reuters: Top News]
Gerbstadt says some foods could theoretically work by mimicking powerful and potentially dangerous drugs such as benzodiazepine that boost the action of the brain chemical gamma-aminobutyric acid (GABA) in the central nervous system.. [Do you know which of these will help you sleep?]
Medication, most commonly anti-anxiety drugs, such as benzodiazepine and its derivatives, also may be required in some cases.. [MyLinkVault Newest Links]
"benzodiazepine," you're barking up entirely the wrong arboriform growth.. [Yahoo! Video Games: Top Features]
Valerian root has properties that resemble the benzodiazepine class of medications such as Valium and Xanax, but Scharf says he has no idea how they compare with standard sleeping pills because of the lack of comparative studies.. [Can relaxation drinks put you to sleep?]
According to the report, the opioid-poisoning death rate increased by 20% and the benzodiazepine death rate went up 17% between 2005 and 2009, a time when the city's overall drug overdoses decreased.. [Abuse of Pills Jumps in City, Report Shows]
Cocaine was third, with an estimated 180,000 users in the past year, followed by the 90,000 who said they took pills containing the anti-anxiety drug benzodiazepine.. [Abuse of Pills Jumps in City, Report Shows]
When anxiety is excessive, he prescribes tranquilizers in the benzodiazepine class, including Valium, Klonopin, Ativan, Serax and Xanax, but only after a thorough review of the patient's well being and current medications.. [Glenn C. Altschuler: Seasonal Affective Disorder: The Birth of the Blues]
Sleeping pills, of which the most common are the older benzodiazepines like valium (diazepam), clonazepam (klonopin), ativan (lorazepam), restoril (temazepam), and the like, hit all three of benzodiazepine receptors and still do not produce fully natural sleep.. [Matthew Edlund, M.D.: Alcohol and Sleeping Pills: The 'Perfect' Night's Sleep?]
It works by hitting one of the three benzodiazepine receptors in the brain.. [Matthew Edlund, M.D.: Alcohol and Sleeping Pills: The 'Perfect' Night's Sleep?]
Darragh A, Lambe R, Kenny M, Brick I. Tolerance of healthy volunteers to intravenous administration of the benzodiazepine antagonist Ro 15-1788.. [Flumanazil]
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