Boronic

Various forms of the boron compounds, known as boronic esters, are commercially available, says Hou. ❋ Unknown (2008)

Usually when you catch one and open it, you'll find the tank full of ugly chemicals like lithium pentafluorophenyl borate etherate, methoxyphenyl-boronic acid or naphthylboronic acid. ❋ Unknown (2006)

The molecules the team used are all benzene-boronic acids that interact strongly with hydrogen in their own right. ❋ Unknown (2010)

Importantly, the team found that EGCG only reacted with proteasome inhibitors that have a boronic acid base (including bortezomib) but did not react with several non-boronic acid-based proteasome inhibitors (such as nelfinavir [Viracept (R)], a treatment for HIV). ❋ Unknown (2009)

The analysis of the study offered a clear understanding of the boronic acid-related mechanisms that cause the negative outcome, offering the conclusion that green tea would counteract most, if not all, compounds that work with boronic acid. ❋ Unknown (2009)

However, while there are many chemicals that contain boronic acid, few are being used with patients. ❋ Unknown (2009)

The researchers determined that the boronic acid in bortezomib helped to bind the EGCG directly to the therapy molecule, thereby cancelling out the effects of both the green tea and the therapy on the tumor cells. ❋ Unknown (2009)

Importantly, the team found that EGCG only reacted with proteasome inhibitors that have a boronic acid base (including bortezomib) but did not react with several non-boronic acid-based proteasome inhibitors (such as nelfinavir [Viracept®], a treatment for HIV). ❋ Unknown (2009)

When the team analysed the biochemical interaction between the two compounds they discovered that EGCG interacts with a boronic acid unit, which forms part of the Velcade molecule, preventing the drug binding to its target in the cancer cell. ❋ Unknown (2009)

(2-methylcyclohexyl boronic acid) [8] 585 (phenyl propargyl selenide) [9] (cyclohexanone) [15] Additional information [8, 15] Specific activity ❋ [email protected](arab2000.forum (2009)

52, 665-671 (1986) [8] Latham, J.A.; Walsh, C.: Retention of configuration in oxidation of a chiral boronic acid by the flavoenzyme cyclihexanone oxygenase. ❋ [email protected](arab2000.forum (2009)