Bupivacaine

Word BUPIVACAINE
Character 11
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Bupivacaine"

What do we mean by bupivacaine?

A potent, long-acting anesthetic, C18H28N2, used for regional anesthesia in its hydrochloride form. noun

A local anesthetic drug of the amino amide group. noun

Here you will find one or more explanations in English for the word bupivacaine. Define bupivacaine, bupivacaine synonyms, bupivacaine pronunciation, bupivacaine translation, English dictionary definition of bupivacaine.

Synonyms and Antonyms for Bupivacaine

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The word "bupivacaine" in example sentences

For that, we use a combination of a local anesthetic called bupivacaine, some opiate medication called fentanyl, and morphine, and that gives you analgesia for almost 24 to 48 hours after the C-section so that you don't require any form of IV pain relief. ❋ Unknown (2008)

ELADUR is a transdermal patch containing bupivacaine, which is designed to provide up to three days of pain relief versus the existing market-leading patch, which is indicated for 12 hours of wear. ❋ Unknown (2008)

Ganesh A, Adzick NS, Foster T, Cucchiaro G. Efficacy of addition of fentanyl to epidural bupivacaine on postoperative analgesia after thoracotomy for lung resection in infants. ❋ Unknown (2010)

Most anesthetic drug names end with the suffix “-caine,” such as lidocaine and bupivacaine. ❋ Penny Simkin (2010)

These data were collected from a total of 446 individuals receiving 75 mg to 750 mg of EXPAREL or bupivacaine HCl across 11 studies.

Business -- Has filed a New Drug Application, or NDA, for the lead product candidate, EXPAREL, a long-acting bupivacaine anesthetic/analgesic product for postsurgical pain management.

Currently under review with the U.S. Food and Drug Administration, EXPAREL is an innovative long-acting bupivacaine that has been evaluated in multiple Phase 2 and Phase 3 clinical studies to assess prolonged postsurgical analgesia for up to 72 hours with a single-dose local administration at the surgical site.

Less pain over 72 hours was demonstrated for patients receiving EXPAREL compared to patients receiving bupivacaine HCl, as evidenced by an area under the curve analysis, a measure of pain over time AUC0-72 315 vs 427, respectively.

The drug combines bupivacaine with DepoFoam®, a proven product delivery technology that encapsulates medications and delivers them over a desired time period.

"These data show that EXPAREL delivers bupivacaine over three days with the well-established DepoFoam carrier matrix, providing postsurgical pain relief while extending the traditional duration of action from seven hours to up to 72 hours," said Dr. Hu.

EXPAREL consists of bupivacaine encapsulated in DepoFoam, which is designed to address the limitations of widely used medications by enhancing their dosing and/or administration profile.

PCRX's clinical data demonstrates that EXPAREL provides analgesia for up to 72 hours post-surgery, compared with seven hours or less for bupivacaine.

December 2010, Pacira announced that its New Drug Application (NDA) for EXPAREL (bupivacaine liposome extended-release injectable suspension), the company's most advanced investigational product candidate, had been accepted for filing by the U.S. Food and Drug Administration (FDA).

Even at doses up to 600 mg, the maximal plasma concentration of EXPAREL was 935 ng/mL, which is 2- to 4-fold below the minimal toxicity threshold for bupivacaine HCl central nervous system effects are usually first seen at bupivacaine levels of

In this study, 107 patients were randomly assigned to one of three treatment groups prior to undergoing elective arthroscopic shoulder surgery: POSIDUR at a dose of 5 mL, an active comparator (commercially available bupivacaine HCI solution) or SABER-Placebo (SABER vehicle without drug).

A 46% reduction in the mean number of ORAEs for patients receiving EXPAREL compared to patients receiving bupivacaine HCl 0.25 vs 0.46, respectively.

EXPAREL bupivacaine liposome extended-release injectable suspension is Pacira's proprietary drug candidate consisting of bupivacaine encapsulated in DepoFoam®, both of which are currently used separately in FDA-approved products.

It is intended to be administered during surgery, where it continuously releases therapeutic levels of bupivacaine in a controlled fashion, providing up to 72 hours of uninterrupted local analgesia.

A 50% reduction in the total amount of morphine-equivalent opioids consumed for patients receiving EXPAREL compared to patients receiving bupivacaine HCl 7.9 mg vs 15.8 mg, respectively.

Cross Reference for Bupivacaine

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What does bupivacaine mean?

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