Camptothecin

Such selectivity would be useful in cancer treatment, because drugs such as camptothecin jam Top1 in all cells, not just cancer cells.

From the Chinese Camptotheca trees, camptothecin is being trialed for breast, prostate, pancreas, ovarian, leukemia, and lymphoma cancers as well as malignant melanoma. ❋ Dr. Reese Halter (2010)

Several other chemotherapy agents have been attached to the linker used for INNO-206, including paclitaxel, camptothecin, cisplatin and methotrexate, and may be incorporated into future clinical development by the Company.

The chemotherapy drug camptothecin and ionizing radiation both attack cancer cells by causing double-strand DNA breaks. ❋ Unknown (2010)

When a mutant that cannot be SUMOylated is substituted for RPA70, the repair process is defective, giving the cell increased sensitivity to camptothecin and radiation. ❋ Unknown (2010)

Camptotheca acuminata is a major natural source of the terpenoid indole alkaloid camptothecin (CPT). ❋ Unknown (2010)

Presents dynamics and variability of the protein response of human cancer cells to a chemotherapy drug, camptothecin. ❋ Unknown (2010)

The mutation results in loss of RAD51 focus formation in response to DNA damage and in increased cellular sensitivity to the DNA interstrand cross-linking agent mitomycin C and the topoisomerase-1 inhibitor camptothecin. ❋ Fiona Vaz (2010)