July 2010 after the PDCO recommended CTI expand the original PIP to include pixantrone's potential clinical benefit of reducing long-term cardiotoxicity associated with current curative therapies in children. ❋ Unknown (2010)
"Some may conclude that establishing this hurdle of long, costly trials for drugs that have no suggestion of cardiotoxicity will stifle drug development for Type 2 diabetes," the FDA said. ❋ Unknown (2008)
Antidepressants that have less cardiotoxicity and fewer anticholinergic side effects are preferable desipramine, nortriptyline, fluoxetine. ❋ Michael Alan Taylor (1993)
Herceptin is also associated with cardiotoxicity due to previous treatment with doxorubicin; this is also expected to be eliminated with the use of the T-DM1 conjugate. ❋ Unknown (2011)
Their usage has been hampered by side effects, particularly, cardiotoxicity. ❋ Unknown (2010)
Older tricyclic antidepressants may increase mortality from cardiovascular disease when used therapeutically and are often fatally toxic in overdose, whereas selective serotonin reuptake inhibitors (SSRIs) show little if any cardiotoxicity at any dose, although, their antiplatelet effect has potential for harm. 2 The serotonin-noradrenaline reuptake inhibitor venlafaxine has been thought to show cardiovascular toxicity somewhere between that of tricyclics and SSRIs, so its use has been restricted in some countries. ❋ Taylor, D. (2010)
Roche says that it is already running screens based on stem cells to test drugs for cardiotoxicity and effects on neurogenesis. ❋ Unknown (2010)
His group was one of the first to report that survivors of childhood cancer faced not only acute cardiotoxicity from treatment, but also late cardiac effects. ❋ Unknown (2010)
These novel pharmacologic differences may allow re-introduction of anthracycline like potency in the treatment of relapsed/refractory aggressive lymphoma without unacceptable rates of cardiotoxicity. ❋ Unknown (2010)
In addition, the structural motifs on anthracycline-like agents that are responsible for the generation of oxygen free radicals and the formation of toxic drug-metal complexes have also been modified in pixantrone to prevent the binding of iron and perpetuation of superoxide production -- both of which are the putative mechanism for anthracycline induced acute cardiotoxicity. ❋ Unknown (2010)
In addition, CTI believes the structural motifs on anthracycline-like agents that are responsible for the generation of oxygen free radicals and the formation of toxic drug-metal complexes have also been modified in pixantrone to prevent the binding of iron and perpetuation of superoxide production--both of which are the putative mechanism for anthracycline induced acute cardiotoxicity. ❋ Unknown (2010)
Goshima K, Takeda Y, Sugino Y, Miwatani T (1976) Demonstration of the cardiotoxicity of the thermostable direct hemolysin (lethal toxin) produced by Vibrio parahaemolyticus. ❋ Toshio Kodama Et Al. (2010)
In addition, the structural motifs on anthracycline-like agents that are responsible for the generation of oxygen free radicals and the formation of toxic drug-metal complexes have also been modified in pixantrone to prevent the binding of iron and perpetuation of superoxide production--both of which are the putative mechanism for anthracycline induced acute cardiotoxicity. ❋ Unknown (2010)
Current cardiotoxicity tests, especially at early stages of drug development, tend to focus on one aspect of heart cell function -- the hERG ion channel. ❋ Unknown (2009)
