Coiled-coil containing protein TSGA14 (Cep41) was recently described as a centrosomal component ❋ Vincent Gache Et Al. (2010)
Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. ❋ Unknown (2006)
Molecular characterisation of centrosomal components is slowly progressing. ❋ Unknown (2005)
In what way does centrosomal function rely on liquid propulsion? ❋ Unknown (2005)
The first one, the editor was a strong evolutionary biologist, and his reaction was ‘well, we are not interested in theories of centrosomal function, we just want more molecules, you should just go out and give us those.’ ❋ Unknown (2005)
It is also believed that the centrosomal pathway is, at least partially, redundant in somatic cells and in the absence of centrosomes chromosomes alone can drive spindle formation in mitotic somatic cells ❋ Vincent Gache Et Al. (2010)
The discovery, reported in the article "Arpc 1b, a centrosomal protein, is both an activator and substrate of Aurora A," furthers the science world's understanding of what happens during the fundamental process of mitosis, when cells divide. ❋ Unknown (2010)
Heidelberg and at the Leibniz Institute for Age Research - Fritz Lipmann Institute in Jena have investigated the functions of the different centrosomal components. ❋ Unknown (2010)
Inactivation of a centrosomal protein causes abnormal organisation of the mitotic spindle microtubules and a faulty distribution of chromosomes. ❋ Unknown (2010)
Although centrosomes are absent in oocytes, this finding is not surprising, as many centrosomal proteins interact (directly or indirectly) with microtubules in oocytes and egg extracts. ❋ Vincent Gache Et Al. (2010)
Huntingtin is also heavily expressed and localized to centrosomal regions in dividing cells. ❋ Unknown (2010)
Another centrosomal protein found in our screen, NEDD1, co-precipitates with γ-tubulin complex ❋ Vincent Gache Et Al. (2010)
A few of the centrosomal proteins that we identified are in fact also found on microtubules in meiosis and on interphase microtubules in somatic cells (see above on γ-tubulin and TSGA14). ❋ Vincent Gache Et Al. (2010)
The fact that we found GFP-tagged TSGA14/Cep41 at the spindle in egg extracts and associated with microtubules in interphase cells suggests that this protein may also be a MAP, as many MAPs have both centrosomal and microtubule localization ❋ Vincent Gache Et Al. (2010)
Patel UK, Stearns T (2006) GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. ❋ Vincent Gache Et Al. (2010)
