So, unless the test is able to discriminate, in the cancer cells present in the blood at any given stage of a patient's disease, those cells that will "home", are "clonogenic", etc., it does really not shed much light into prognostication on a patient's urvival, necessity of changing therapeutic plans, etc... ❋ Unknown (2011)
The adult heart contains cardiac stem cells (CSCs) that are self-renewing, clonogenic (able to produce identical daughter cells), and multipotent-ie, they differentiate into all three major cardiac lineages (myocytes, vascular smooth muscle cells, and endothelial cells).
The fact that a cancer cell is found in the blood does in no way mean that it will home in a particular tissue/site and start growing a give rise to a "metastasis"... that cancer cell in the blood should also prove to be "clonogenic", i.e., be capable of replication, survival skills such as angiogenetic mechanisms i.e., provide itself with enough blood supply to grow when it has passed the 1 mm size mark. ❋ Unknown (2011)
ErPC3 was cytotoxic to AML primary cells and reduced the clonogenic activity of CD34 ❋ A M Martelli (2010)
Results showed that C4-2 cells were more likely to survive from irradiation and appeared more aggressive in their resistance to radiation treatment compared with LNCaP, as measured by clonogenic assays and cell viability and cell cycle analyses. ❋ Bang-Xiang Xie (2010)
The current data show that the clonogenic and proliferative capacity of primary human glioblastoma tumor initiating cells is vastly decreased by exposure to imetelstat in vitro, compared to controls. ❋ Javier Zacarias (2010)
We found that overexpression or inhibition of let-7g, miR-189, and miR-20a markedly influenced clonogenic survival and cell proliferation per se. ❋ Mechthild Wagner-Ecker (2010)
(E) The clonogenic potential of the test expanded cells showed a significant increase in the differential colony formation. ❋ Sangeetha V. M Et Al. (2010)
Interestingly, when cultured in foetal calf serum (FBS) or human cord blood serum, MPCs were able to differentiate into highly proliferative and clonogenic MSCs. ❋ Simone Pacini Et Al. (2010)
In the normal state, these cells rarely proliferate unless there is a pressure for increased production of the clonogenic self-renewing progenitor cells, which undergo rapid clonal expansion, followed by differentiation into the mature cells lining the villi. ❋ Payel Bhanja Et Al. (2009)
Survival of the animal depends on the balance between crypt depopulation, and the efficiency and number of the surviving clonogenic cells regenerating the crypts. ❋ Payel Bhanja Et Al. (2009)
Miyamoto T, Akashi K, Weissman IL (2002) Prospective isolation of human clonogenic common myeloid progenitors. ❋ Lina Han Et Al. (2009)
Potten CS (1995) Interleukin-11 protects the clonogenic stem cells in murine small-intestinal crypts from impairment of their reproductive capacity by radiation. ❋ Payel Bhanja Et Al. (2009)
Loss of this regenerating population of clonogenic cells following irradiation prevents the normal reepithelialization of the intestinal villi. ❋ Payel Bhanja Et Al. (2009)
Results siRNA-mediated c-MYC down-regulation resulted in an inhibition of cellular proliferation and clonogenic growth, inhibition of G1-S phase cell cycle progression, and a decrease in human telomerase reverse transcriptase (hTERT) expression and telomerase activity. ❋ Unknown (2009)
In addition, EGCG may have an effect on the clonogenic capacity of the cells. ❋ Dity Natan Et Al. (2009)
However, if one or more 'clonogenic cell' survives the insult, it rapidly proliferates regenerating the crypt within 72-96 hours with subsequent reconstitutions of the villi. ❋ Payel Bhanja Et Al. (2009)
