The activating enzymes are members of a class called enkephalin convertase. ❋ Kenneth Blum (1991)
The activating enzymes in endorphin synthesis are members of a class called endorphin convertase. ❋ Kenneth Blum (1991)
The activating enzyme is a member of a class called dynorphin convertase. ❋ Kenneth Blum (1991)
HOERSHOLM, Denmark and SAN DIEGO, April 26 Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, today announced that it has advanced into drug development a discovery research candidate directed against PCSK9 (proprotein convertase subtilisin/kexin type 9), an important new target for the treatment of high cholesterol. ❋ Unknown (2010)
The mature growth factor dimer is cleaved from the propeptide region by furin convertase proteolysis in the endoplasmic reticulum (ER) at a conserved RSRR sequence ❋ Carlene S. Starck Et Al. (2010)
The peptide minimal binding motif Arg-X - (Arg/Lys) (Arg/Lys) identified by alanine-scan, suggested the target receptor to be a proprotein convertase (PC). ❋ Katarina Hajdin Et Al. (2010)
R, Seidah NG, Prat A (2009) The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. ❋ Katarina Hajdin Et Al. (2010)
Lebel A, McMahon S, Fournier I, Fugere M, et al. (2003) TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity. ❋ Katarina Hajdin Et Al. (2010)
Alnylam has an ongoing development program focused on using RNAi therapeutics targeting proprotein convertase subtilisin/kexin type 9, or PCSK9, as a novel strategy for reducing LDL (or "bad") cholesterol. ❋ Unknown (2010)
Of those, MASP-2 is essential as it cleaves C4 and C2 components, leading to the formation of the classical C3 convertase ❋ Alvaro Cervera Et Al. (2010)
Study determines that a specific enzyme, known as pro-protein convertase 4 (PC4) may be responsible for fetal growth restriction, the second leading cause of infant mortality in the developed world. ❋ Unknown (2009)
Now as a doctoral candidate, he focuses on the proprotein convertase subtilisin / kexin type 9, or PSCK9 gene, which encodes an enzyme that regulates cholesterol and formatively impacts cardiovascular health.
C3 is cleaved to form C3a and C3b by C3 convertase. ❋ Crisbertc (2009)
Lazure C (2003) Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes. ❋ Ajoy Basak Et Al. (2009)
Kowalska D, Liu J, Appel JR, Ozawa A, Nefzi A, et al. (2009) Synthetic small-molecule prohormone convertase 2 inhibitors. ❋ Ajoy Basak Et Al. (2009)
