Cyclase

When guanylyl cyclase is activated, it starts to produce cyclic GMP from GTP. ❋ Unknown (1998)

a specific isoform of cyclic GMP phosphodiesterase and allowing cyclic GMP to accumulate when guanylate cyclase is activated by nitric oxide released from the nerves innervating the erectile tissue. ❋ Unknown (1999)

Cyclic AMP is synthesised from ATP via the enzyme adenylyl cyclase, which is in turn activated by G-proteins coupled to the V2 receptors. ❋ Unknown (2009)

Beuve and Duran's study shows nitroglycerin modifies a key molecule called soluble guanylyl cyclase, which is a fundamental mediator in the relaxation of blood vessels. ❋ Unknown (2008)

These cells, called guanylyl cyclase D cells, glowed in the presence of carbon dioxide, showing when mice were picking up the scent. ❋ Unknown (2007)

T cell differentiation via activation of adenylate cyclase. ❋ Unknown (2005)

Iseki M et al., A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis Nature, 2002, 415, 1047-1051 ❋ Unknown (2006)

The effector enzymes vary—it can be adenylate cyclase, which changes the levels of cyclic AMP, or it can be phospholipase C, which generates other signalling molecules, DAG and IP3. ❋ Unknown (2005)

Sutherland and Rall had already shown in brain slices that several neurotransmitters known to exist in the brain could increase the concentrations of cAMP by activating the enzyme adenylyl cyclase that converted ATP to cAMP. ❋ Unknown (2001)

Schwartz and Cedar next found that the transmitter serotonin could also increase cAMP, providing the initial evidence that serotonin might activate an adenylyl cyclase in ❋ Unknown (2001)

After an incredibly long and tedious series of experiments, each often lasting for 96 consecutive hours, we found the heme in purified guanylate cyclase. ❋ Unknown (1999)

A long and tedious series of experiments in my laboratory led to the discovery that thiols were required for the activation of guanylate cyclase by nitroglycerin and related nitrovasodilators. ❋ Unknown (1999)

IX, activated heme-deficient guanylate cyclase by kinetic mechanisms that were indistinguishable from the mechanism by which nitric oxide activates heme-containing guanylate cyclase. ❋ Unknown (1999)

Subsequent experiments revealed that the presence of enzyme-bound heme was an absolute requirement for guanylate cyclase activation by nitric oxide. ❋ Unknown (1999)

I recall reading an interesting paper by Ferid Murad's group in 1977, in which nitric oxide and various nitro compounds were shown to activate the cytosolic form of guanylate cyclase and to elevate cyclic GMP levels in various tissues. ❋ Unknown (1999)

Having elucidated the mechanism of action of nitroglycerin as a vasodilator, the next step was to understand how nitric oxide activates guanylate cyclase. ❋ Unknown (1999)

EDRF and nitric oxide were both chemically unstable and both activated guanylate cyclase and elevated tissue levels of cyclic GMP. ❋ Unknown (1999)