These findings are similar to those in obese rats, which have reduced NK cell cytotoxicity which is restored upon weight loss ❋ Donal O'Shea Et Al. (2010)
Determine the dispersant concentration that induced cytotoxicity in multiple cell lines and derive an aggregate measure of cytotoxicity that could be use to rank order the chemicals and to compare with in vivo toxicity data obtained in aquatic test species. ❋ Unknown (2010)
ANTITUMOR Immune enhancement; activating macrophages, T cells, and NK cells; increasing TNF-α production; inducing cancer cell apoptosis and cytotoxicity ❋ M.D. Nicholas Perricone (2010)
Natural cytotoxicity, assumed to be an important defense mechanism in viral, neoplastic, and parasitic diseases, was also reduced. ❋ Unknown (2009)
The 10-year study began with an EPA grant to develop mammalian cell lines that would be used specifically to analyze the ability of these compounds to kill cells, or cytotoxicity, and the ability of these emerging disinfection by-products to cause genomic DNA damage. ❋ Unknown (2009)
T cells identify antigens, and the antigen-sensitised T cells produce cytokines and other soluble factors which mediate the hypersensitivity reaction, or else they develop cytotoxicity. ❋ Steve Carper (2006)
For example, often a chemical is tested with both human and animal cells to study its ability to produce cytotoxicity, mutations, and DNA damage. ❋ Unknown (2007)
A fractionated extract of Astragalus membranaceus potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2. ❋ Dr. Kenneth R. Pelletier (2000)
We started to cooperate on immune responses against the LCMV virus; he was tapping the cerebral spine fluid and doing the inflammatory and immunopathological analyses in the brains, while I was doing the cytotoxicity assays, since I had become familiar with them in Lausanne. ❋ Unknown (1997)
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic and semiallogeneic system. ❋ Unknown (1996)
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngenic and semiallogeneic system. ❋ Unknown (1996)
Relatively little is understood about the T-cells and the B-cells, but even less is known about the “killer” K-cells, which are involved in an immune phenomenon called “antibody-dependent cell-mediated cytotoxicity.” ❋ Ph.D. Richard A. Passwater (1991)
Therefore, one can expect that structural modifications of these compounds to suppress cytotoxicity, if feasible, can be performed to give modified compounds which might be safe antimalarials However, up to now such modifications have not been performed (Phillipson, 1990). ❋ Unknown (1991)
CYT997 is an orally-available small molecule therapeutic with dual mechanisms of vascular disruption and cytotoxicity, and is currently in a Phase II trial for glioblastoma multiforme.
IV and oral dose formulations with dual mechanisms of vascular disruption and cytotoxicity.
PolyMedix tested several of its defensin-mimetic antibiotic compounds that are well-tolerated and exhibit low cytotoxicity, including one that is a close structural analog of PMX-30063, in an animal model against
