Deamidation

However, in the more alkaline environment (higher pH) a chemical process called deamidation converts Bcl-xL into a form that allows cells with damaged DNA to die. ❋ Unknown (2009)

This is the first demonstration of a role for deamidation in human malignancy. ❋ Unknown (2009)

The therapeutic interest in this research comes from the authors 'finding that simply switching back on the Bcl-xL deamidation pathway causes the cancer cells to die. ❋ Unknown (2009)

As expected, Imatinib was unable to restore the Bcl-xL deamidation pathway in the patient's cells. ❋ Unknown (2009)

The authors have discovered that it is these kinases that block the key Bcl-xL deamidation pathway that normally allows DNA damaged cells to die. ❋ Unknown (2009)

So drug resistance can be overcome by activating the NHE-1 pathway, thereby increasing the pH inside the cell, and in turn Bcl-xL deamidation and apoptosis. ❋ Unknown (2009)

Stretching this analogy further, it is also possible to suggest that Asn and Gln can be arginylated with or without deamidation, that lysine (Lys) can accept Arg onto its side chain amino group, and that serine, threonine, and Cys can be arginylated on the side chains after oxidation. ❋ Unknown (2008)

(green) and deamidation (blue) represent in vitro artifacts of the mass spectrometry experiment. ❋ Dana M. Gwinn Et Al. (2010)

(+15.99), deamidation of Asn and Gln (+0.984) and Cys alkylation (+57.02). ❋ Dana M. Gwinn Et Al. (2010)

It has been previously suggested that N-terminal asparagine (Asn) and glutamine (Gln) require deamidation in order to be arginylated [ ❋ Unknown (2008)