Deaminase

This system is largely responsible for our ability to generate stronger and faster resistance to subsequent infections, and is integral to why vaccines work. 3 recent papers used concepts in evolution to help characterize one of the most interesting and novel immunological genes discovered since the RAGs in the late 80s, a gene called activation induced deaminase AID, pronounced as initials, a gene pivotal to antibody modification. ❋ Unknown (2010)

Thus a deaminase is an enzyme which contains deaminations and oxidase is one which contains oxidizing. ❋ Unknown (2009)

The first approved GM procedure was performed in 1990 when NIH scientists genetically modified white blood cells in Ashanti DeSilva, a four-year-old girl with adenosine deaminase deficiency ❋ Gannett, Lisa (2008)

Ashanti DeSilva inherited two broken copies of the gene that contains the instructions for manufacturing a protein called adenoside deaminase (ADA). ❋ Unknown (2005)

However, at the turn of the millennium, a gene called activation induced deaminase AID was discovered to be essential for all three processes. ❋ Unknown (2006)

Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. ❋ Unknown (2006)

Structural phylogenetic analysis of activation-induced deaminase function. ❋ Unknown (2006)

Moreover, diaminopurine riboside was a poorer substrate for adenosine deaminase than was adenosine. ❋ Unknown (1988)

He found that 9 - (2-hydroxyethoxymethyl) - adenine could still serve as a substrate for adenosine deaminase. ❋ Unknown (1988)

Acyclovir is a metabolic product of the diaminopurine derivative, formed by the action of adenosine deaminase and is undoubtedly responsible for the antiviral activity of the diamino compound observed in vivo (110-112). ❋ Unknown (1988)

He had been studying analogs of adenosine as substrates and inhibitors of the enzyme adenosine deaminase, and had examined a variety of acyclic side chains on the ❋ Unknown (1988)

Ph. D., professor in the Division of Neurology at the University of British Columbia, to deliver a prodrug-activating enzyme (cytosine deaminase) to brain tumor sites. ❋ Unknown (2010)

"Bubble boy" disease: severe combined immunodeficiency (SCID) due to a lack of an enzyme called adenosine deaminase. ❋ Govindab (2010)

To investigate the potential applicability of the mNUS promoter for biotechnological needs, a construct carrying a recombinant cytosine deaminase (RCD) suicide gene under the control of mNUS was tested in cell lines of different tissue origin. ❋ Denis Kuzmin (2010)

Activation-induced cytidine deaminase (AID) is a B-cell-specific DNA mutator that plays a key role in the formation of the secondary antibody repertoire in germinal center B cells. ❋ Unknown (2010)

Researchers discovered that adenosine deaminase (AD), an enzyme, may prevent priapism from progressing to penile fibrosis ❋ Unknown (2010)

Error bars indicate s.e.m. Figure 4: Pharmacological inhibition of deaminase activity enhances increases in adenosine and prolongs anti-nociception actions of acupuncture. ❋ Nanna Goldman (2010)

The nucleoside analog deoxycoformycin inhibits both AMP deaminase (AMPD) and adenosine deaminase (ADA). ❋ Nanna Goldman (2010)