Defensin

They have found that bees make a protein that they add to the honey, called defensin-1, which could one day be used to treat burns and skin infections and to develop new drugs that could combat antibiotic-resistant infections. ❋ Unknown (2010)

These AMPs are basically endogenously produced antibiotics with names like defensin 2, defensin 3, and cathelicidin. ❋ Grrm (2010)

Led by University of Cincinnati scientists, the team found that skin cells that were genetically altered to produce higher levels of a protein known as human beta defensin 4 killed more bacteria than normal skin cells. ❋ Unknown (2007)

Another possible intervention for such couples might ultimately be synthetic forms of beta defensin 126 that can be added to sperm. ❋ Unknown (2011)

"You can concentrate it in a vaginally applied cream or gel, and sperm would pick up this defensin coat as they advanced into the cervix," Cherr said. ❋ Unknown (2011)

PolyMedix will engage the CAB members to actively collaborate on the clinical development of its novel defensin-mimetic antibiotic ❋ Unknown (2010)

In addition, their presence within the beta-defensin repeat raises the question whether they may contribute to the influence of this repeat on immune related conditions. ❋ Unknown (2010)

Researchers at Montreal's McGill University Health Center and University of Montreal found vitamin D acts directly on the beta defensin 2 gene, which encodes an anti-microbial peptide and the NOD2 gene that alerts cells to the presence of invading microbes. ❋ Unknown (2010)

They found that vitamin D acts on two genes -- defensin 2 and NOD2 -- that have been linked to ❋ Unknown (2010)

"This award will provide the opportunity to further develop the medical device applications of our defensin-mimetic technology, which could provide clinicians with important additional weapons in the fight against surgical site infections." ❋ Unknown (2010)

PolyMedix has received 9 grants and research contracts from the National Institutes of Health and branches of the military to help support the development of its defensin-mimetic antibiotic compounds. ❋ Unknown (2010)

Proteins have always played an important part in this armoury, and a broad variety of defensin proteins have become part of the immune system of plants, insects and other animals except mammals. ❋ Unknown (2010)

There is evidence, Cole explained, that it contains a peptide called human beta defensin 1 that may help keep a urinary tract infection from reaching the kidneys. ❋ Unknown (2010)

The PolyCide polymers, like PolyMedix's novel defensin-mimetic compounds, including its lead systemic antibiotic drug PMX-30063, are synthetic mimetics of the host-defense proteins, one of the oldest and most effective antimicrobial defense systems found in humans and virtually all living creatures. ❋ Unknown (2010)

PolyMedix completes Phase 1B clinical study with PMX-30063 defensin-mimetic antibiotic ❋ Editors (2010)

They found that vitamin D significantly increased the level of an antibacterial peptide called beta-defensin, as well as NOD2, a protein that alerts cells to the presence of germs. ❋ Unknown (2010)