Demethylase

"Three years ago, we discovered the jumanji family of histone demethylase, which is a huge family and brought big interest in the field to study this group of genes." ❋ Unknown (2009)

Conversely, the researchers found, blocking the expression of a protein called Rbr-2 taxed with removing the tag - a demethylase - shortened the worm's life span by about 15 to 25 percent. ❋ Unknown (2010)

A Jumonji C family histone 3 lysine-27 (H3K27) demethylase, Jmjd3, plays a crucial role in macrophage plasticity and inflammation. ❋ PLoS ONE (2010)

Disruption of the PHD domain binding to H3K4me3 reduced the demethylase activity in vivo, and loss of ceKDM7A reduced the expression of its associated target genes. ❋ Hanqing Lin (2010)

(KDM7A) as a novel histone demethylase specific for these two repressing marks. ❋ Chengyang Huang (2010)

Institute, tested the normal enzyme function of histone demethylase in zebrafish, a popular model for genetic function. ❋ Unknown (2010)

Thus, our study identifies a dual-specificity histone demethylase and provides novel insights into the regulation of histone methylation. ❋ Hanqing Lin (2010)

The scientists dubbed the enzymes thebaine 6-O-demethylase and codeine O-demethylase. ❋ Unknown (2010)

Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation ❋ Eric Metzger (2010)

Biochemical and structural studies reveal that PHF8 is a novel histone demethylase specific for di - and mono-methylated histone H3 lysine 9 (H3K9me2/1), but not for H3K9me3. ❋ Lin Yu (2010)

Thus, our study identified a dual-specificity histone demethylase that regulates neural differentiation through FGF4. ❋ Chengyang Huang (2010)

Xiang Y, Zhu Z, Han G, Ye X, Xu B, et al. (2007) JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. ❋ Roy Blum Et Al. (2009)

Chen Y, Zhao Y, Bruick RK (2007) JMJD6 is a histone arginine demethylase. ❋ Unknown (2009)

Presentation Title: Novel oligoamine / polyamine analogues inhibit lysine-specific demethylase 1 (LSD1), induce re-expression of epigenetically silenced genes, and inhibit the growth of established human tumors in vivo ❋ Unknown (2009)