Best, and under my direction, he succeeded in 1922 in showing that such extracts reduced the hyperglycaemia and glycosuria in depancreatized dogs. ❋ Unknown (1965)
The general symptoms of diabetes were also found to be alleviated and the duration of life of the depancreatized animal prolonged, by the repeated injection of alcoholic extracts of foetal, as well as of adultox pancreas. ❋ Unknown (1965)
These results on depancreatized dogs showed beyond doubt that the antidiabetic hormone was present in potent form in the extracts, and the time seemed ripe to investigate their action on the clinical forms of diabetes. ❋ Unknown (1965)
Thus, one of the depancreatized dogs gave birth to five pups without any change whatsoever in her sugar balance throughout the pregnancy, although, on the day after the pups were born, severe symptoms of hypoglycaemia developed, no doubt because of the removal of glucose from the body to form the lactose of the milk. ❋ Unknown (1965)
And finally permit me to say something concerning the behaviour of depancreatized animals kept alive by means of insulin. ❋ Unknown (1965)
With the collaboration of Frank N. Allan, I.L. Chaikoff, J. Markowitz, and W.W. Simpson, several completely depancreatized dogs have now been kept alive, by daily injections of insulin, for many months, the operation on * one of them, which is at present under observation, having been performed over eighteen months ago. ❋ Unknown (1965)
It had been known that depancreatized dogs were unable to store glycogen in the liver, and that glycogen disappears in three or four days after pancreatectomy. ❋ Unknown (1965)
Following the intravenous injection, the blood sugar of the depancreatized dogs was reduced to a normal or subnormal level, and the urine became sugar-free. ❋ Unknown (1965)
But with the daily administration of this whole gland extract we were able to keep a depancreatized dog alive and healthy for ten weeks. ❋ Unknown (1965)
The extracts prepared in this way were tried on depancreatized dogs and in all cases the blood sugar was lowered. ❋ Unknown (1965)
In August 1921they depancreatized two dogs and treated one with pancreatic extract leaving the other as a control. ❋ Unknown (2009)
Even were the gland allowed to degenerate for a sufficient time so that all acinar tissue had disappeared - which is considerably over a year in the rabbit - it would be difficult, in the event that extracts of the residue still contained insulin, to be certain that this insulin is not of the type which it is possible to extract from various materials, including even the tissues of depancreatized animals, as Best and Scott have shown. ❋ Unknown (1965)
