Diphenylmethane

Other nonbarbiturate sedatives-hypnotics include (1) glycol or glycerol derivatives (e.g., meprobamate) and (2) diphenylmethane derivatives (e.g., diphenhydramine, hydroxyzine). ❋ Michael Alan Taylor (1993)

These investigators found that by the condensation of phenols and hydroxybenzoic acids with formaldehyde, diphenylmethane derivatives were formed; pyrogallol yields hexahydroxydiphenylmethane -- ❋ Georg Grasser (N/A)

Nierenstein considers this reaction analogous to the formation of cork, to the genetic relation of which with the diphenylmethane formation Drabble and Nierenstein have referred in an earlier publication. ❋ Georg Grasser (N/A)

With the introduction of the carboxylic group the tendency of condensation to diphenylmethane derivatives is lessened; by protocatechuic acid the tendency is nil. ❋ Georg Grasser (N/A)

Dekker [Footnote: "De Looistoffen," vol. ii, p. 30 (1908).] was, however, unable to detect diphenylmethane on distilling with zinc dust, and did, therefore, not accept Nierenstein's views. ❋ Georg Grasser (N/A)

With gelatine and aniline hydrochloride it exhibits reactions similar to those given by the diphenylmethane condensation products; its tanning properties also are similar to those of the latter. ❋ Georg Grasser (N/A)

Nierenstein (see above), however, emphasises that the high molecular weight and the optical activity speak against the digallic acid formula, but in favour of this are the following points: (1) the decomposition of tannin with the formation of gallic acid; (2) the decomposition of methylotannin with the formation of di - and trimethyl esters of gallic acid; and (3) the production of diphenylmethane on distillation with zinc dust. ❋ Georg Grasser (N/A)

In the benzene series this reaction is difficult to establish, and has to be induced by distilling the particular dihydroxy-diphenylmethane at ordinary pressure. ❋ Georg Grasser (N/A)

Effective today, there are no longer any restrictions on the company's ability to supply diphenylmethane diisocyanate ❋ Unknown (2008)