In particular, the researchers wanted to see whether the density of the receptors changes, because when dopamine is plentiful, dopamine receptors 'downregulate' - that is, move from the nerve-cell membrane to the inside of the cell, where they cannot be activated. ❋ Unknown (2009)
They also downregulate enzymes that synthesize fat. ❋ M.D. Nicholas Perricone (2010)
Narbonne and Roy found that C. elegans larvae that lack a certain signaling pathway (the LKB1/AMPK pathway to be precise), which is activated during dauer, quickly downregulate fat mobilization so that lipid reserves are rationed to last the entire duration of the arrest. ❋ Unknown (2008)
Technically, it allows your brain to downregulate receptors and adapt to normal chemistry. ❋ Unknown (2009)
Paradoxically, dramatically spiking caloric intake in this way once per week increases fat loss by ensuring that your metabolic rate thyroid function, etc. doesn't downregulate from extended caloric restriction. ❋ Unknown (2009)
How long before your thryroid function, and other metabolic functions ‘downregulate?’ ❋ Unknown (2008)
Insulin stays elevated and in a diabolical twist even stimulates more fat synthesis in the liver and tends to downregulate the insulin receptors, making them less responsive. ❋ Unknown (2008)
If statins, which downregulate HGM-CoA reductase, also block CoQ10 production… does glucagon do something similar affect CoQ10? ❋ Unknown (2007)
This is so that your metabolism doesn't get used to a lower calorie load and downregulate itself.
We all need healthy, non-caloric, non-alcoholic ways to downregulate our emotions in a crisis. ❋ M.D. Alicia Salzer (2011)
Blood monocytes from tumor-bearing mice exhibit a mixture of inflammatory and anti-inflammatory genes and downregulate differentiation markers. ❋ Unknown (2010)
So if MIP-1β is taking up all the available CCR5 slots, or the bounty of MIP-1β around causes the cell to downregulate CCR5, those cells would be protected from HIV-1 infection! ❋ ERV [email protected] (2010)
Meier R, Seitz M, Dewald B, Baggiolini M, et al. (1992) Glucocorticoids downregulate gene expression of gm-csf, nap-1/il-8, and il-6, but not of m-csf in human fibroblasts. ❋ Gang Wu Et Al. (2010)
