The logical first step, then, is to protect the cell before damage occurs, including the cell membrane, mitochondria, and DNA, as well as the downregulation of inflammatory genes. ❋ M.D. Nicholas Perricone (2010)
As insulin loses function, more insulin is required, more insulin leads to more downregulation of receptors, all of which ultimately leads to obesity. ❋ Unknown (2008)
In gaining muscle mass, one of his recommendations is to “drop calories by 50% one day per week to prevent protein uptake downregulation.” ❋ Unknown (2008)
Conversely, NFAT3 downregulation results in actin reorganization associated with increased migration and invasion capabilities. ❋ M Fougère (2010)
Using western blot and immunofluorescence, a downregulation of dystrophin and β-dystroglycan expression in both severe and moderate injury could be observed in septic hearts. ❋ Mara Rúbia N Celes (2010)
Moreover, co-expression of both rat α-syn and α-syn siRNA partially reversed the neurodegenerative and behavioral effects of α-syn plays an important role in the rat SNc and suggest that both up - and downregulation of wild-type ❋ Unknown (2010)
Although from a statistical point of view this group of inducible genes is underrepresented as compared to what is expected, the possibility should not be discounted that transcriptional downregulation of an enhancer may be involved in the activation of the associated gene, possibly by relieving transcriptional interference ❋ Francesca De Santa Et Al. (2010)
Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, et al. (2006) Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death. ❋ Donald Courter Et Al. (2010)
We conclude that RA treatment leads to premature downregulation of Oct4 and partial derepression of Xist irrespective of X-chromosome counting. ❋ Janice Ahn (2010)
A key proposition that underpins our understanding of dosage sensitivity is that duplication or deletion of the genomic region containing a gene will result in a significant up - or downregulation of expression of the gene ❋ Benjamin Schuster-B�ckler Et Al. (2010)
Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient ❋ Janice Ahn (2010)
Examination of various SNc neuronal markers indicated that neurodegeneration was due to cell loss and not just downregulation of DA synthesis. ❋ Oleg S Gorbatyuk (2010)
One study has also shown that dexamethasone (DEX) contributed to the downregulation of MAM-induced IL1B and TNF -. ❋ Gang Wu Et Al. (2010)
Chen X, Hu DN, Dong XD, et al. (2009) MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. ❋ Mitchell S. Stark Et Al. (2010)
Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients ❋ Marie-Hélène Lafage-Proust (2010)
This in turn triggers downregulation of superoxide dismutase and catalase (CAT) activities that have essential roles in oxidative detoxification in mammals. ❋ Wai Han Yiu (2010)
