Dystroglycan

With this new grant, Campbell and his colleagues, including Matthew Goddeeris, Ph. D., will study several types of muscular dystrophy that result from deficient glycosylation (addition of sugar molecules) of a muscle protein called dystroglycan. ❋ Unknown (2010)

Saito F, Chen J, Michele DE, Henry MD, et al. (2002) Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. ❋ Samir Koirala Et Al. (2010)

You guess the rest ... dystroglycan 5: 13PM (4/06/2010) ❋ Devon Brozek (2010)

There are also a variety of membrane receptors that bind LG domain of laminins: syndacans, a-dystroglycan, and integrins. ❋ Ashcraft (2010)

The dystrophin-deficiency phenotype varies from a severe Duchenne-type to the milder allelic form known as Becker muscular dystrophy (BMD), determined in part by the location of the mutation in relation to the actin and dystroglycan binding domains and, in particular, by the mutation's effect on the reading frame ❋ Gemma L. Walmsley Et Al. (2010)

Beedle will examine how the timing of dystroglycan disruption during muscle development increases or decreases the severity of muscle disease. ❋ Unknown (2009)

The study will also investigate whether restoring normal dystroglycan can lessen or prevent muscle damage in mice. ❋ Unknown (2009)

Several different genetic mutations can disrupt dystroglycan function and cause muscular dystrophy. ❋ Unknown (2009)

(Media-Newswire. com) - Aaron Beedle, Ph. D., an associate in molecular physiology and biophysics at the UI Carver College of Medicine, has received a two-year, $120,000 grant from the Muscular Dystrophy Association to study muscular dystrophies caused by abnormalities in a protein called dystroglycan. ❋ Unknown (2009)

Beta-dystroglycan, the core component of the dystrophin-glycoprotein complex that is responsible for attaching dystrophin to the muscle membrane, also was missing, which suggested that a loss of ankyrin-B is linked to a loss of at least two key proteins in the cell membrane, Bennett said. ❋ Unknown (2009)

They found that the cells needed ankG to help dystrophin and beta-dystroglycan stay in place at the costameres. ❋ Unknown (2009)

Hayashi YK, Ogawa M, Tagawa K, Noguchi S, Ishihara T, et al. (2001) Selective deficiency of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy. ❋ Unknown (2008)