Endomesoderm

Figure 9.3 is an illustration of the genetic regulatory system that turns on the genes that control the construction of a tissue called the endomesoderm in sea urchins. ❋ Michael J. Behe (2007)

Although work is tentative and is continuing, the number of protein factors known to be involved in the gene regulatory network for B cell differentiation is similar to the number involved in the endomesoderm kernel about ten.36 The authors comment: ❋ Michael J. Behe (2007)

FIGURE 9.3 Schematic drawing of a developmental gene regulatory network for sea urchin endomesoderm. ❋ Michael J. Behe (2007)

Kernels in general can be expected to have a degree of complexity similar to that for sea urchin endomesoderm, so we can infer that other kernels also were designed. ❋ Michael J. Behe (2007)

Livi CB, Davidson EH (2006) Expression and function of blimp1 / krox, an alternatively transcribed regulatory gene of the sea urchin endomesoderm network. ❋ Unknown (2009)

Collectively, these observations strongly suggest that a micromere-derived, ActivinB-dependent signal is necessary for early veg2 endomesoderm progenitor specification through the outputs of a discrete set of core factors of the E-EM / En subnetworks. ❋ Unknown (2009)

This critical finding, along with the fact that, like micromere progeny, ActivinB is required for normal endo16 expression in veg2 endomesoderm progenitors, and for timely gastrulation, strongly suggests that this TGFβ ligand plays an essential role in early micromere-dependent endomesoderm specification. ❋ Unknown (2009)

These observations strongly suggest that Pmar1-misexpressing blastomeres respecify presumptive ectoderm as endomesoderm by activating only part of the E-EM / En-GRN, consisting of the genes encoding the core regulatory factors Z13, Eve, and FoxA. ❋ Unknown (2009)