This comes at a time when psychiatry is looking beyond the current diagnostic manuals as the sole definition of mental disorder, and considering the concept of the 'endophenotype' - measurable aspects of biology thought to be the key underlying components that increase risk for mental disorder. ❋ Unknown (2005)
Link to academic paper on the 'endophenotype' concept. ❋ Unknown (2005)
Yes, the genetics of it are complicated, it's an area of interest viz work for me, but I think the point I was trying to make was more along the lines of how genetics interacts with human culture and history and nurture (the latter leading to the 'endophenotype') to produce selection that isn't the straightforward natural selection process in the wild - of survival of the fitest in the wild. ❋ Unknown (2009)
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. ❋ MD Mark Hyman (2010)
Chen P, Jou YS, Fann CS, Chen JW, Chung CM, et al. (2009) Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides. ❋ Unknown (2009)
Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, et al. (2007) Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. ❋ Unknown (2009)
The McGirr and colleagues study is the most explicit and comprehensive examination of impulsive aggression as a putative endophenotype for suicidal behavior yet reported. ❋ Unknown (2009)
One candidate endophenotype for suicidal behavior is the trait of "impulsive aggression," which may be defined as the tendency to respond to provocation or frustration with hostility or aggression. ❋ Unknown (2009)
B traits, and mediation of familial transmission of suicidal behavior via the transmission of the trait of impulsive aggression that can be raised about impulsive aggression as an endophenotype for suicidal behavior. ❋ Unknown (2009)
Gottesman II, Gould TD: The endophenotype concept in psychiatry: etymology and strategic intentions. ❋ Unknown (2009)
Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ❋ Unknown (2008)
Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders. ❋ Unknown (2008)
We also examined alcohol sensitivity, which is an established endophenotype for alcohol dependence. " ❋ Unknown (2009)
In order for a trait to be considered an endophenotype, it must be 1) associated with the condition, 2) heritable, 3) state independent, 4) a tract that cosegregates with the condition, and 5) found in the unaffected relatives of those with the condition at a higher than expected rate. ❋ Unknown (2009)
