Exocytotic

Zonta M, Pozzan T, Vicini S, Carmignoto G (2001) Cytosolic calcium oscillations in astrocytes may regulate exocytotic release of glutamate. ❋ Marta Gómez-Gonzalo Et Al. (2010)

UDP-sugar release includes an exocytotic component. ❋ J. I. Sesma (2009)

We hypothesized that compromised RPE will remove damaged intracellular macromolecules without completely digesting them by increasing exocytotic activity. ❋ Unknown (2009)

Intracellular overload of damaged macromolecules leads to increased exocytotic activity. ❋ Unknown (2009)

Although we have not studied any one process in detail, our findings link aspects of aging, oxidative stress, mtDNA damage, autophagy, lysosomal activity, exocytotic activity as functional processes of RPE that have changed in the aged eye. ❋ Unknown (2009)

We hypothesized that RPE cells with decreased lysosomal activity and increased exocytotic activity will release signals for recruitment of leukocytes, particularly macrophages, to aid in the digestion of extracellular deposits. ❋ Unknown (2009)

We then asked whether we could find evidence for increased exocytotic activity in the RPE / choroid with age. ❋ Unknown (2009)

We provide the first evidence for an apparent increased exocytotic activity in the aging RPE. ❋ Unknown (2009)

Here, we provide the first evidence for increased autophagy and increased exocytotic activity in the aged RPE and the presence of autophagy and exosome markers in drusen of AMD patients. ❋ Unknown (2009)

[3], [31] and the intracellular proteins that are found in exosomes Comparison, from the literature, of exosome proteome and drusen proteome We hypothesize that, in the aged RPE in vivo, there is age-related, increased exocytotic activity lead to the release of intracellular proteins via exosomes which contribute to the formation of drusen. ❋ Unknown (2009)

By in vitro modeling increased mtDNA damage induced by rotenone, an inhibitor of mitochondrial complex I, in the RPE, we found that the phagocytic activity was not altered but that there were: 1) increased autophagic markers, 2) decreased lysosomal activity, 3) increased exocytotic activity and 4) release of chemoattractants. ❋ Unknown (2009)