Thus, as a practical matter, sequencing the exome is a high-value, more affordable alternative to sequencing the entire genome. ❋ Kevin Davies (2010)
The first step is to sequence 1 percent of each volunteer's genome, focusing on the so-called exome — the protein-coding regions that, Church suspects, do 90 percent of the work in our DNA. ❋ Unknown (2008)
A Yale team led by Murat Gunel has already used partial genome sequencing of the 1.5 percent of the genome, called the exome, that codes for proteins to determine the cause of a mysterious and still unnamed genetic disease that results in severe brain malformations. ❋ Unknown (2012)
Your genome is the sequence of all your DNA; your exome is a subset of your genome that contains the part of the DNA that codes for the genes.
The exome is the portion of the genome that contains genes that code for proteins. ❋ Unknown (2011)
For the first time, scientists have successfully used a method called exome sequencing to quickly di ... ❋ Editors (2010)
In their study, the team used a new type of genomics technology called exome sequencing to find the mutation in the valosin-containing protein VCP gene, which has been described as a molecular "chaperone" aiding various cellular activities such as protein breakdown. ❋ Unknown (2010)
This research represents a "real-world" case in human genetics and provides strong evidence that targeted sequencing of the exome is a revolutionary technology to efficiently identify potential disease-causing genes. ❋ Unknown (2010)
The Sanger Institute (where I work) has formally announced the launch of the UK10K Project, which will sequence the whole genomes of 4,000 people at low coverage, as well as sequencing all of the protein-coding genes (collectively known as the exome) of a further 6,000 people. ❋ Unknown (2010)
Within the last year, the combination of DNA capture approaches with cheap, large-scale sequencing technology has made it technically feasible to simply sequence every known protein-coding gene in the genome (in combination known as the exome) to hunt for possible mutations. ❋ Unknown (2009)
For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder. ❋ Unknown (2009)
The research, published by Cell Press on July 29th in the American Journal of Human Genetics, demonstrates that sequencing an affected individual's entire "exome"; that is, all of the genes that carry instructions for producing proteins, can reveal critical genes that when mutant, cause inherited disorders. ❋ Unknown (2010)
These will include rare variants in protein coding regions of the genome (the "exome") as well as in regulatory regions. ❋ Unknown (2009)
From the outset, Conde decided that Knome would offer whole-genome sequencing, rather than a compromise “exome” approach,3 concentrating on the 1 to 2 percent of the genome that codes for protein, which appealed to Church. ❋ Kevin Davies (2010)
Murim Choi et al., “Genetic diagnosis by whole exome capture and massively parallel DNA sequencing,” Proceedings of the National Academy of Sciences USA 106 2009, 19096–19101. ❋ Kevin Davies (2010)
As it was still not economically feasible to sequence ten whole genomes at $100,000 a pop, Church chose to focus on just the genes, the 1 to 2 percent of the genome known in the trade as the exome that code for proteins, where most of the medically relevant variants reside. ❋ Kevin Davies (2010)
Even as those results came in, technology continued to improve, and the new schizophrenia study takes advantage of a technique called whole exome sequencing. ❋ John Timmer (2011)
Instead of looking for large-scale changes like CNVs, exome sequencing focuses on small changes that take place in key areas: the one to two percent of the human genome that actually codes for proteins this portion is contained in things called exons, hence the term "exome". ❋ John Timmer (2011)
