Fibrogenic

Most of the fibrogenic cells in the liver are a-smooth muscle actin-expressing myofibroblasts and most are derived from the transdifferentiation of hepatic stellate cells. ❋ Unknown (2010)

Through the use of isolated cells in culture, animal model systems, and banked human tissue, researchers in the FSBPLC are studying the major populations of fibrogenic cells in biliary atresia and are identifying the factors (some specific to this disease) that induce these cells to secrete abnormal and excess matrix. ❋ Unknown (2010)

Ghrelin, a stomach hormone, reduced the amount of fibrogenic cells by 25% in the treated rodents. ❋ Unknown (2010)

Our results demonstrated that Withagulatin A potently inhibited HSC viability and type I procollagen production, thereby implying that this natural product has potential use in the development of anti-fibrogenic reagents for the treatment of hepatic fibrosis. ❋ Unknown (2010)

In a recent study, Brack et al have demonstrated that in aged animals which show significant muscle wasting, the conversion of satellite cells from a myogenic to a fibrogenic lineage occurs due to the activation of the canonical Wnt signaling pathway ❋ Siva K. Panguluri Et Al. (2010)

Pathologically, airway remodeling appears to have a variety of features that include an increase in smooth muscle mass, mucus gland hyperplasia, persistence of chronic inflammatory cellular infiltrates, release of fibrogenic growth factors along with collagen deposition, and elastolysis (Figure 3).