Flavivirus

Infection with the dengue flavivirus, which is related to West Nile Virus and Yellow Fever, annually results in an estimated half a million hospitalisations and 22,000 deaths, mostly among infants, according to WHO. ❋ Unknown (2009)

My abiding interest in infectious disease caused me to focus on the tickborne flavivirus, louping-ill virus, which was then regarded as problematic because of concerns about the safety of the vaccine, first developed at the Moredun many years previously. ❋ Unknown (1997)

The cause: The disease is caused by the yellow fever virus, which belongs to the flavivirus group. ❋ Unknown (1999)

This mosquito was also a carrier of the flavivirus that caused dengue. ❋ Unknown (2010)

"Finding this novel flavivirus in bats significantly broadens the host range of GB-like agents and may provide insights into the origins of hepatitis C," added Thomas Briese, PhD, lead molecular biologist on the team and ❋ Unknown (2010)

RNA interference (RNAi) induced by exogenous small interfering RNAs (siRNAs) has shown promise for treatment of flavivirus infections in hosts and prevention of transmission by vectors. ❋ Swati Mukherjee (2010)

While the group's focus has been on West Nile Virus, Chen believes the plant-based antibody approach could provide highly effective, cost efficient therapeutics for other diseases, including related flavivirus infections such as dengue fever and Japanese encephalitis, if the successes in mice can be replicated in humans. ❋ Unknown (2010)

The process has been studied in some detail in dengue fever, a related flavivirus. ❋ Unknown (2010)

"Finding this novel flavivirus in bats significantly broadens the host range of GB-like agents and may provide insights into the origins of hepatitis C," added Thomas Briese, PhD, lead molecular biologist on the team and Mailman School associate professor and associate director of CII. ❋ Unknown (2010)

However, the impact of RNAi triggered by authentic virus infection on replication of DENV, or any flavivirus, has received little study. ❋ Swati Mukherjee (2010)

Key flavivirus discovery could lead to vaccines against mosquito and tick diseases ❋ Unknown (2009)

Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, et al. (2004) Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. ❋ Unknown (2009)