Fluorouracil

One of the most commonly used creams contains a chemotherapy drug, called fluorouracil, which destroys the precancerous cells by blocking essential cellular functions within them. ❋ Unknown (2011)

(July 20, 2009) -- Two genes may contribute to chemotherapy resistance in drugs like 5-fluorouracil, which is used in liver cancer treatment, according to Virginia Commonwealth University Massey Cancer Center researchers. ❋ Unknown (2009)

Rep. Cummings said PRN Pharmaceuticals of Rockville, Md., offered to sell another cancer drug, fluorouracil, for $350 per vial. ❋ Jennifer Corbett Dooren (2011)

Of the 140,000 patients diagnosed with colorectal cancer each year, about 80,000 are expected to rely on typical treatments such as fluorouracil or leucovorin, both currently in short supply, said Nancy Roach, a board member at the patient group Fight Colorectal Cancer. ❋ Unknown (2011)

FUSILEV enhances the cyto-toxicity of fluorouracil. ❋ Unknown (2011)

The paper did look at patients who had failed fluorouracil treated patients, one of the types of drugs that patients must have failed to enter the phase 3 trial.

Spermatogonial was curiously inhibited by fluorouracil, fantasizing in pathogenic infertility. ❋ Unknown (2010)

Histone modifications represent novel prognostic and predictive biomarkers that could inform clinical decisions, including use of fluorouracil (5-FU) chemotherapy. ❋ Unknown (2010)

* TAXOTERE in combination with cisplatin and fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck ❋ Unknown (2010)

* TAXOTERE in combination with cisplatin and fluorouracil is indicated for the treatment of patients with advanced gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior treatment ❋ Unknown (2010)

Histone modifications represent novel prognostic and predictive biomarkers that could inform clinical decisions, including use of fluorouracil ❋ Editors (2010)

High levels of two specific histone modifications in the tumor cells of patients who underwent surgical resection of their pancreatic cancer predicted which patients were more likely to derive survival benefit from the chemotherapy drug fluorouracil, or 5-FU. ❋ Unknown (2010)

We reported previously (Jan. 3, 2008, issue) 1 that capecitabine and oxaliplatin are as effective as infused fluorouracil and cisplatin, respectively, in patients with previously untreated esophagogastric cancer that was inoperable and either locally advanced or metastatic. ❋ Unknown (2010)

Chemotherapy agents used in the radiation-plus-chemotherapy group included Platinol® (cisplatin) and fluorouracil. ❋ Unknown (2010)

Conclusion Among the RCTs included, postoperative adjuvant chemotherapy based on fluorouracil regimens was associated with reduced risk of death in gastric cancer compared with surgery ❋ The GASTRIC (Global Advanced/Adjuvant Stomach Tumo (2010)

Objectives To perform an individual patient-level meta-analysis of all RCTs to quantify the potential benefit of chemotherapy after complete resection over surgery alone in terms of overall survival and disease-free survival, and to further study the role of regimens, including monochemotherapy; combined chemotherapy with fluorouracil derivatives, mitomycin C, and other therapies but no anthracyclines; combined chemotherapy with fluorouracil derivatives, mitomycin C, and anthracyclines; and other treatments. ❋ The GASTRIC (Global Advanced/Adjuvant Stomach Tumo (2010)