Acyclovir (brand name: ZOVIRAX), the oral version of ganciclovir, is taken three times a day for 100 days after the transplant. ❋ Unknown (2009)
The FDA said that it had not blocked importation of the generic antiviral ganciclovir, which is also made at the facilities, on the basis that Ranbaxy is the sole supplier to the US market. ❋ Unknown (2008)
Antiviral agents such as ganciclovir and valacyclovir are already in routine clinical use for treating active viral infections. ❋ Unknown (2010)
Consequently, ganciclovir has proven to be a much better inhibitor of HCMV replication than acyclovir (132-134). ❋ Unknown (1988)
Tomicic M, Klocking R, Wutzler P, Kaina B (2000) Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir. ❋ Donna N. Douglas Et Al. (2010)
AiCuris says that AIC246 also demonstrated efficacy in the treatment of one patient who had developed viremia due to HCMV that was resistant to ganciclovir, foscarnet, and cidofovir. ❋ Unknown (2010)
The development of CMV CNS disease is associated with risk factors (T-cell depletion, anti-thymocyte globulin, umbilical cord blood transplantation) that cause severe and protracted T-cell immunodeficiency (8 of 11 cases), a history of recurrent CMV viremia treated with multiple courses of preemptive ganciclovir or foscarnet therapy (11 of 11 cases), and ganciclovir-resistant CMV infection (11 of 11 cases). ❋ S M Reddy (2010)
Elshami AA, Saavedra A, Zhang H, Kucharczuk JC, Spray DC, et al. (1996) Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. ❋ Donna N. Douglas Et Al. (2010)
Sirion Therapeutics Announces Availability of Zirgan (TM) (ganciclovir ophthalmic gel) 0.15% for Ocular Herpes innovation in the US topical ophthalmic antiviral class in 30 years ❋ Unknown (2010)
The herpes simplex virus type-1 thymidine kinase (HSV tk)/ganciclovir (GCV) system is a powerful tool for cell-specific ablation in transgenic animals. ❋ Donna N. Douglas Et Al. (2010)
Despite therapy with a combination of antiviral drugs (ganciclovir, foscarnet and cidofovir), mortality is high (10 of 11 cases). ❋ S M Reddy (2010)
Tsukamoto A (1995) Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir. ❋ Donna N. Douglas Et Al. (2010)
Mutagenesis van der Eb MM, Cramer SJ, Vergouwe Y, Schagen FH, van Krieken JH, et al. (1998) Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration. ❋ Donna N. Douglas Et Al. (2010)
Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, et al. (1993) Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. ❋ Donna N. Douglas Et Al. (2010)
Magnelli L, Chiarugi VP, Israel MA (1996) Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. ❋ Donna N. Douglas Et Al. (2010)
