With a genome size of ~580 kb and approximately 480 protein coding regions, Mycoplasma genitalium is one of the smallest known self-replicating organisms and, additionally, has extremely fastidious nutrient requirements. ❋ Unknown (2009)
I taking it there would be no disagreement that Mycoplasma genitalium is life, since it is a full fledged organism. ❋ Unknown (2007)
BTW, Shall I take it you agree that Mycoplasma genitalium is life? ❋ Unknown (2007)
The reduced genomic content of M. genitalium has led researchers to suggest that the molecular assembly contained in this organism may be a close approximation to the minimal set of genes required for bacterial growth. ❋ Unknown (2009)
The object of interest for the purpose of this blog entry is an organism known as Mycoplasma genitalium. ❋ Unknown (2009)
… Was [M. genitalium] the minimum, or could we eliminate genes from that species and get smaller? ❋ Unknown (2007)
This required dismantling M. genitalium, which suggested another possibility: If you could take a genome apart bit by bit, why not put one together in the same way, creating “life from scratch,” as Venter puts it, with a genome of your choice? ❋ Unknown (2007)
In January 2008, a team of 17 researchers at the JCVI created the largest man-made DNA structure by synthesizing and assembling the 582,970 base pair genome of a bacterium, Mycoplasma genitalium JCVI-1. 0. ❋ Unknown (2009)
The DNA sequence is based on the bacterium Mycoplasma genitalium which the team pared down to the bare essentials needed to support life, removing a fifth of its genetic make-up. ❋ Unknown (2007)
This stripped-down genome has been established with the help of a simple bacterium, Mycoplasma genitalium, by knocking out its genes, one by one, until only the genetic material vital for survival was found. ❋ Unknown (2007)
Here is the link which has an applet that "… displays a gene map of the complete genome of Mycoplasma genitalium" ❋ Unknown (2007)
From here, the team devised a five stage assembly process where the cassettes were joined together in subassemblies to make larger and larger pieces that would eventually be combined to build the whole synthetic M. genitalium genome. ❋ Glyn Moody (2008)
Craig Venter Institute JCVI has created the largest man-made DNA structure by synthesizing and assembling the 582,970 base pair genome of a bacterium, Mycoplasma genitalium JCVI-1.0. ❋ Glyn Moody (2008)
This company, Synthetic Genomics, I'm involved with, created the first full synthetic genome for a little bug, a very primitive creature called Mycoplasma genitalium. ❋ Barry Schuler (2008)
This is the map of a small organism, Mycoplasma genitalium, that has the smallest genome for a species that can self-replicate in the laboratory. ❋ Unknown (2008)
