If the urine is acidic, the weak acids (such as glucuronide and sulfate conjugates) are less ionized and undergo reabsorption with renal excretion reduced. ❋ Unknown (2007)
"Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat." ❋ Unknown (2010)
The glucuronide conjugation of aniline is illustrated below: ❋ Unknown (2008)
The primary Phase II reactions are: glucuronide conjugation - most important reaction sulfate conjugation - important reaction acetylation amino acid conjugation glutathione conjugation methylation ❋ Unknown (2008)
With 7-10 times the recommended therapeutic level, the sulphate and glucuronide conjugation pathways become saturated and more of the toxic metabolite is formed. ❋ Unknown (2008)
At normal doses, approximately 96% of acetaminophen is biotransformed to non-toxic metabolites by sulfate and glucuronide conjugation. ❋ Unknown (2008)
The glucuronide conjugates are generally quite hydrophilic and are excreted by the kidney or bile, depending on the size of the conjugate. ❋ Unknown (2008)
However, enzymes in the intestinal flora are capable of hydrolyzing some glucuronide and sulfate conjugates, which can release the less-polar compounds that may then be reabsorbed. ❋ Unknown (2007)
The preparation using human liver microsomes converted BPA to the glucuronide metabolite at a significantly lower rate than did the rat microsomes. ❋ Unknown (2007)
In contrast, lorazepam and oxazepam are excreted unconjugated, or as the glucuronide, and have a half-life of 12 to 18 hours. ❋ Michael Alan Taylor (1993)
As such there are no in vivo data on the rate at which unconjugated BPA is converted to bisphenol A-glucuronide in humans, only predictions ❋ David Melzer Et Al. (2010)
The resveratrol molecule is metabolized or 'conjugated' by both the liver and small intestine into primarily two related metabolites: resveratrol glucuronide and resveratrol sulfate. ❋ Unknown (2010)
These include two embryonic o-glucuronide sensibles ❋ Unknown (2010)
Mpa is supplied just by beta lol propranolol 10 mg transferase to scoop the attendance glucuronide of mpa ❋ Unknown (2010)
Mpa is presented considerably by clonidine propranolol synergetic transferase to salud the cis glucuronide of mpa (mpag) which is also pharmacologically active. ❋ Unknown (2010)
Many of these effects have been reported to occur at concentrations below recommended safe daily exposure levels, prompting much recent debate on the requirement for revision of current legislation Once ingested BPA is metabolised to form the highly water soluble major metabolite, bisphenol A-glucuronide. ❋ David Melzer Et Al. (2010)
Slide 38: 3 alpha androstanediol glucuronide •Metabolite of DHT •Good marker of peripheral androgen action •Inc {increased activity of 5 alpha reductase} {end organ hypersensitivity} •Not done routinely: 1. ❋ Unknown (2009)
Dihydrtestosterone (DHT) Androstanediol Glucuronide 3 alpha androstanediol glucuronide (3 alpha AG) ❋ Unknown (2009)
Samples were subjected to enzymatic hydrolysis using beta-glucuroni-dase / sulfatase enzyme for deconjugation of conjugated glucuronide and sulfonate forms of the target analytes (the completeness of hydrolysis was monitored by the recovery of 4-methylumbelliferone). ❋ Unknown (2008)
Urine samples were first buffered with ammonium acetate buffer and then spiked with a labeled triclosan standard solution, 13C4-4-methylumbelliferone, and 4-methylumbelliferyl glucuronide, and beta-glucuronidase enzyme (for deconjugation of possible glucuronidated forms of the target analyte). ❋ Unknown (2008)
