Haemoglobinuria

In 1901-1903 Landsteiner pointed out that a similar reaction may occur when the blood of one human individual is transfused, not with the blood of another animal, but with that of another human being, and that this might be the cause of shock, jaundice, and haemoglobinuria that had followed some earlier attempts at blood transfusions. ❋ Unknown (1965)

He made fundamental contributions to our knowledge of paroxysmal haemoglobinuria. ❋ Unknown (1965)

This study confirmed that G6PD deficiency is strongly associated with haemoglobinuria ❋ Nguyen Hue (2009)

Socié G, Mary J Yves, de Gramont A, et al. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors.

Recent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria.

Iwanga M, Furukawa K, Amenomori T, et al. Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes.

Eighty-two haemoglobinuria patients and 524 healthy controls were screened for G6PD deficiency using either the methylene blue reduction test, the G-6-PDH kit or the micro-methaemoglobin reduction test. ❋ Nguyen Hue (2009)

The G6PD variants within the Vietnamese Kinh contributing to the disease risk in this population, and more generally to haemoglobinuria, are currently unknown. ❋ Nguyen Hue (2009)