Hamartomas

Cowden syndrome is an inherited disorder characterized by multiple tumor-like growths called hamartomas, and an increased risk of certain cancers. ❋ Unknown (2008)

Patients with PHTS disorders usually develop multiple benign (noncancerous) growths known as hamartomas in different areas of the body. ❋ Unknown (2009)

In addition to hamartomas, patients can have other clinical features, including: ❋ Unknown (2009)

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of hamartomas, which are unusual tumor-like growths found in a variety of tissues ❋ Unknown (2008)

TSC1 or TSC2 genes, is characterized by the development of hamartomas. ❋ Unknown (2008)

MAPK-dependent phosphorylation of tuberin may lead to somatic inactivation of the hamartin / tuberin complex in tuberous sclerosis complex-associated brain hamartomas that have activated MEK1 and ERK1 ❋ Elena Lesma Et Al. (2008)

Usually skin hamartomas exist, and commonly (about 66\% of cases) hamartoma of the thyroid gland exists. ❋ Unknown (2008)

Some lung hamartomas can compress surrounding lung tissue to a degree, but this is generally not debilitative or even noticed by the patient, especially for the more common peripheral growths. ❋ Unknown (2008)

Cowden Syndrome or Cowden Disease is a serious genetic disorder characterized by multiple hamartomas. ❋ Unknown (2008)

The hamartomas themselves may cause symptoms or even death, but morbidity is more often associated with increased occurrence of malignancies, usually in the breast or thyroid. ❋ Unknown (2008)

Lung hamartomas are more common in men than in women, and may present additional difficulties in smokers. ❋ Unknown (2008)

There is a strong association between cardiac rhabdomyomas and tuberous sclerosis (characterized by hamartomas of the central nervous system, kidneys and skin, as well as pancreatic cysts; ❋ Unknown (2008)