In the search for answers to these questions, suspicion fell most strongly on a reaction catalyzed by an enzyme called hexokinase (hek'soh-ky'nays). ❋ Asimov, Isaac (1963)
It reduced levels of glycolytic enzymes such as hexokinase, phosphoglucoisomerase and aldolase levels, which are increased in hepatoma-bearing rats, and increased levels of gluconeogenic enzymes such as glucose. 6-phosphatase and fructose-I ❋ Unknown (2009)
Early on, Meyerhof's group spent considerable effort to investigate the effects of hexokinase, which Meyerhof had discovered in 1927. ❋ Unknown (2010)
ANTIDIABETES Improving the secretion of insulin by repairing damaged pancreatic beta-cells; promoting the absorption of glucose in the liver; inhibiting the release of glucose from the liver by increasing hexokinase activity; reducing glucose-6-phosphatase activity ❋ M.D. Nicholas Perricone (2010)
Glucose transport is rapid so that the first irreversible step, hexokinase, must determine the rate of net flux. ❋ Unknown (2005)
Thus any condition that affects the rate of glucose utilization of red cells must do so by either having an effect on G6P or on the activity of the hexokinase itself. ❋ Unknown (2005)
A problem that warrants further study derives from our observation in 1967 that instead of being in the cytosol most of the hexokinase of tumor and animal cells is associated with the outer membrane of the mitochondrial fraction26. ❋ Unknown (2005)
Subsequently, our lab used the pulse/chase method to study hexokinase in the steady state by comparing the 14C-G6P formed in an acid quench with that formed in a high substrate chase with time of quenching, ❋ Unknown (2005)
A remarkable effect of Pi in stimulating red cell glycolysis was traced to its interference with the binding of G6P to the enzyme without itself having an effect on the hexokinase rate20. ❋ Unknown (2005)
We used yeast hexokinase with 14C-glucose (the pulse) followed by ATP plus a large excess of unlabeled glucose (the chase). ❋ Unknown (2005)
We did pulse/chase experiments in which the labeled glucose came from hexokinase in the crystalline state either alone or together with ADP31. ❋ Unknown (2005)
It has recently been reported that the release of mitochondrial hexokinase and some associated proteins may play a role in the onset of the apoptosis cascade27. ❋ Unknown (2005)
Of Meyerhof's many achievements, perhaps the most important is his proof that, in isolated but otherwise intact frog muscle, the lactic acid formed is reconverted to carbohydrate in the presence of oxygen, and his preparation of a KC1 extract of muscle which could carry out all the steps of glycolysis with added glycogen and hexose-diphosphate in the presence of hexokinase derived from yeast. ❋ Unknown (1965)
But the perpetual question, which we meet already in Luther's catechism: «How does it take place?» has remained unanswered until the discovery - published by Cori's Institute - that hormones intervene chemically in the hexokinase reaction. ❋ Unknown (1964)
Your discovery of the hormonal regulation of the hexokinase reaction would seem to lead to a new conception of how hormones and enzymes cooperate. ❋ Unknown (1964)
Two years ago a great sensation was aroused in the scientific world when the Cori's, together with Price, Colowick and Slein, announced that this hexokinase reaction was promoted by insulin but checked by another hormone in extracts from the anterior lobe of the pituitary gland, the hypophysis. ❋ Unknown (1964)
The reaction is promoted by the enzyme hexokinase. ❋ Unknown (1964)
Subsequently, by a study of the action of hormones on hexokinase, they observed that some pituitary extracts inhibit this enzyme in vivo and in vitro and that insulin counteracts this inhibition. ❋ Unknown (1964)
The Coris maintained that the hexokinase reaction was under continual inhibition under ordinary circumstances and that the action of insulin was to counteract this inhibition and to allow the reaction to proceed. ❋ Asimov, Isaac (1963)
