Ongoing studies involve cell-cycle regulation, novel transcription factors and regulation of key genes involved in T cell anergy and tolerance, including Foxp3 and its various homologs; further details are available. ❋ Unknown (2010)
Genes in the universal ancestor that were already homologs of each other (the paralogs such as elongation factors EF-1and EF-G used to root the universal tree, for instance [37]) of course complicate this view. ❋ Unknown (2009)
Do the various parts of the machine have homologs that are in turn part of a system that is more ancient than the machine? ❋ Unknown (2009)
Highly conserved protein interaction motifs and co-expression in sponges of multiple proteins whose homologs interact in eumetazoan synapses indicate that a complex protein scaffold was present at the origin of animals, perhaps predating nervous systems. ❋ Unknown (2007)
Of the 6,968 protein families that have so-called homologs – proteins that have similar amino acid sequences, often reflecting a similar or related function among the species — they found that Chlamy shared 35% (2,489/6,968) with both flowering plants and humans, and an additional 10% (706/6,968) with humans but not with flowering plants. ❋ Unknown (2007)
They draw on Hartman's and Federov's work on eukaryotic signature proteins (ESPs) – that is, proteins that are widespread in eukaryotes but with no homologs in prokaryotes. ❋ Unknown (2007)
Total number "unique" (no known homologs): 15 (36%) ❋ Unknown (2006)
Thus the present scenario predicts that careful multiple alignment of FliH sequences with bacterial F0-b and the corresponding archaeal and eukaryotic homologs (all of which would be equally related to FliH) will confirm homology. ❋ Unknown (2006)
Sure, you identified the bulk of homologs for the Flagellum but you failed for two critical proteins. ❋ Unknown (2006)
Jackson and Plano (2000) report that the Yersinia pestis FliH homolog YscL (corresponding to SctL/HrpE in Figure 4a) has low but significant sequence similarity with the e subunit of the archaeal ATPase of Methanococcus jannaschii and the e subunit of the vacuolar ATPase of Desulfurococcus spp.; these subunits are the homologs of the b subunit of the F1F0-ATP synthetase. ❋ Unknown (2006)
Notably, mutations that increase the activity of human homologs genes descended from a common ancestral DNA sequence of the yeast SCH9 and RAS2 genes play central roles in many human cancers... ❋ Unknown (2008)
And homologs have a very well known evolutionary pathway. ❋ Unknown (2006)
Perhaps interest in fusion models arose because BLAST searches suggest that different eukaryotic coding sequences are sometimes more closely related to archaeal homologs and other times more closely related to bacterial homologs. ❋ Unknown (2006)
Of these we remove interactions that are also observed with the best homologs of these Pnew proteins. ❋ Pedro Beltrao (2007)
As Matzke puts it personal communication: “of 42 so-called standard flagellar proteins in Escherichia coli/Salmonella, only 20 are universally required/detectable in all flagella, only 15 have no known homologs, and only two are both universally required and have no homologs.” ❋ Unknown (2007)
See note 2 And never mind the minor point that dynein for example has cytoplasmic versions with diverse transport functions in the cell apart from intraflagellar transport, including involvement in mitosis, and the fact that dynein itself is the primary motor protein of cilial motility, and that dynein has widespread homologs in eukaryotes and prokaryotes. ❋ Unknown (2007)
Comparisons of the complete genome sequences of flagellated bacteria revealed that the flagellum is based on an ancestral set of 24 core genes for which homologs are present in genomes of all bacterial phyla. ❋ Unknown (2007)
That [alligator] looks [gay] [maybe] he’s a homologator ❋ Jealous Croc (2018)
"[Homologism] is rampant in my church. Everybody there assumes that you agree with waiting until marriage to have sex, even though most people won't actually care if you do it."
"I'm so tired of the way my roommate keeps homologising me. Yes, we are both gay, but that doesn't mean I agree with her that bisexual people are just afraid to come all the way [out of the closet]. [Bisexuality] is a real thing." ❋ Blamtastical (2015)
buying a crossmember from one seller, control arms from another, [air bags] from another, [brackets] from another, [a rack] from another, then trying to put them all together to make one kit - this homologation is one f-ed up homologated mess. ❋ Therapist Tom (2010)
[My dad] is a homosexuologist. He [studies] [homosexuality]. ❋ Kwang (2003)
1. "You [homologous pair]"
2. "[That's so] homologous pair like" ❋ Dr. Bipolar P.H.D. (2007)
1. "You [homologous pair]"
2. "[That's so] homologous pair like" ❋ Dr. Bipolar P.H.D. (2007)
[Professor X] talked for like an hour about why S(2,5,7) bounds a [homology] 4-ball. Talk about an [integral homology coboredism] to the 3-sphere. ❋ NowThatsASpicyMeatball (2020)
