Hydralazine

Certain drugs, notably hydralazine, which is used to treat hypertension, and procainamide, which is used to treat irregular heartbeat, can trigger lupus attacks in people who have no history of the disease. ❋ ROBIN DIBNER (1994)

PERSONALIZED RESPONSE 1. BiDil is a combination of two generic drugs: isosorbide dinitrate and hydralazine I/H. ❋ Kevin Davies (2010)

Taylor et al., “Combination of isosorbide dinitrate and hydralazine in blacks with heart failure,” New England Journal of Medicine 351 2004, 2049–2057. ❋ Kevin Davies (2010)

African-Americans seem to benefit less than Caucasians from ACE inhibitors, but respond better to a combination of two older drugs -- hydralazine and nitroglycerin -- that are now being marketed as a single pill under the name BiDil. ❋ Unknown (2007)

Duster, president of the American Sociological Association, writes that research on isosorbide dinitrate and hydralazine (BiDil), produced by NitroMed, incorrectly links a biological idea of race to heart disease and that socioeconomic factors better explain susceptibility to heart disease. ❋ Unknown (2005)

- If no improvement after one week: hydralazine (PO): 100 mg/d divided in 3-4 doses (up to double this if needed) or methyldopa (PO): 750 to 1500 mg/d divided in 3 doses ❋ Unknown (1993)

- Infusion: dilute 4 ampoules in 500 ml sodium chloride 0.9%; increase infusion rate progressively up to 30 drops/minute; do not dilute in glucose solutions which inactivates hydralazine. ❋ Unknown (1993)

- Eclampsia hydralazine (ampoule de 20 mg/ml, 1 ml) in infusion, protect from light, 4 ampoules of 20 mg in 500 ml 5 % glucose, delivered at 30 drops/minute, until normal BP achieved. ❋ Unknown (1993)

NicOx is not acquiring any rights to BiDil (isosorbide dinitrate / hydralazine hydrochloride). ❋ Unknown (2009)

"Beta blockers and ace inhibitors can be used after the delivery and hydralazine is safe to use during pregnancy," he said. ❋ Unknown (2009)

The most common drugs that cause lupus are procainamide, hydralazine, isoniazid, penicillin and similar antibiotic drugs, and drugs that increase a persons sensitivity to the sun, including tetracycline drugs and sulfa drugs ❋ Unknown (2009)

Drugs such as clonazepam, hydralazine, may also vary. sulphonamides, isoniazide, nitrazepam and procai - The mephenytoin metabolic pathway is utilized namide undergo acetylation in the liver. ❋ Martins0105 (2009)

Unwittingly taking hydralazine for high blood pressure instead of the allergy ❋ Unknown (2009)

Strengthened recommendations on two medications, hydralazine and isosorbide dinitrate, which relieve pressure on the heart by relaxing blood vessels and are particularly effective in African Americans ❋ Unknown (2009)

NitroMed of Lexington, Massachusetts is the maker of BiDil� (isosorbide dinitrate / hydralazine hydrochloride), an orally administered medicine available in the United States for the treatment of heart failure in self-identified black patients. ❋ Unknown (2009)