Hypermethylated

Significantly, they are often found de-methylated in normal cells, but hypermethylated in cancer cells ❋ Cswanson (2010)

In the primary tumours, island 2 was hypermethylated in 14. 5% of the samples and island 4 was hypermethylated in 54% of the samples. ❋ Edneia Ramos (2010)

The ESR1 promoter was hypermethylated in 41% of breast tumour samples. ❋ Edneia Ramos (2010)

Subsequent to Sm core assembly, the snRNA cap is hypermethylated by the TGS1 methyltransferase to form 2,2,7-trimethylguanosine ❋ Shelton S. Bradrick Et Al. (2009)

(H3K4me3), are present in all the unmethylated promoters analysed, and both of them are lost when these promoters become hypermethylated. ❋ Unknown (2009)

We observed colocalization of hypomethylated R-DMRs with hypermethylated C-DMRs and bivalent chromatin marks, and colocalization of hypermethylated R-DMRs with hypomethylated C-DMRs and the absence of bivalent marks, suggesting two mechanisms for epigenetic reprogramming in iPS cells and cancer. ❋ Akiko Doi (2009)

Lin X, Nelson WG (2003) Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells. ❋ Unknown (2009)

↵ † We found that, in MET-treated mice (5.2 mmol / kg twice a day for 7 days), ≈ 5\% of the total gene promoters are hypermethylated when measured by DNA methylation microarrays (NimbleGen, 5mC - ChIP-chip) (unpublished data). ❋ Unknown (2008)

5-Aza-2-deoxycytidine treatment is thought to lead to the reactivation of aberrantly hypermethylated genes ❋ Christopher A. Hamm Et Al. (2009)