As it turns out, a very similar gene, Atonal homolog 1, controls the development secretory cells in the lining of the colon in both humans and mice — and, as Bossyut and his team discovered, inactivating Atoh1 in mice triggers the onset of colon cancer. ❋ Matthew Guerrieri (2009)
Who needs the chance? one responded, citing a standard method of inactivating viruses with heat and pressure. ❋ Betsy McKay (2011)
This was an entirely novel concept: many drugs on the market used to treat autoimmunity are aimed at inactivating TNF-alpha. ❋ Donna Jackson Nakazawa (2008)
Several vaccines are made by taking toxins and inactivating them with a chemical (the toxin, once inactivated, is called a toxoid). ❋ Unknown (2008)
Typically, one of the deletions would “hit” the front end of the gene, while the other deletion might hit the back end in both cases, the functional consequences would be the same—inactivating Rb. ❋ Siddhartha Mukherjee (2010)
By inactivating the toxin, it no longer causes harm. ❋ Unknown (2008)
Activating or inactivating any single gene, he postulated, produced only the first steps toward carcinogenesis. ❋ Siddhartha Mukherjee (2010)
The tetanus vaccine is made by taking the tetanus toxin and inactivating it with a chemical. ❋ Unknown (2008)
Even tamoxifen, the most specific cancer-targeted drug discovered to that date, works by attacking the dependence of certain breast cancer cells on estrogen, and not by directly inactivating an oncogene or oncogene-activated pathway. ❋ Siddhartha Mukherjee (2010)
The diphtheria vaccine is made by taking the diphtheria toxin and inactivating it with a chemical. ❋ Unknown (2008)
The liver is capable of inactivating many environmental toxins and excreting them through the stools or via the kidneys into the urine within hours of exposure. ❋ Unknown (2010)
The pertussis vaccine is made by taking two to five of these toxins and inactivating them with a chemical. ❋ Unknown (2008)
Assuming Knudson was right in his two-hit hypothesis, every eye tumor should possess two independent inactivating mutations in the Rb gene, one in each chromosome. ❋ Siddhartha Mukherjee (2010)
Yet another cell in that secondary mass of cells is caught in the path of an errant X-ray and acquires yet another mutation, this time inactivating a tumor suppressor gene. ❋ Siddhartha Mukherjee (2010)
Genes encode proteins, and proteins often work like minuscule molecular switches, activating yet other proteins and inactivating others, turning molecular switches “on” and “off” inside a cell. ❋ Siddhartha Mukherjee (2010)
Another technique, known as facet joint denervation involves inactivating nerves in the joints that enable the spine to bend and twist, such as in the neck, by passing radio waves via needles inserted through the skin to heat the tissue at the tip of a joint. ❋ Unknown (2010)
The cholera vaccine is made by taking the whole cholera bacteria and killing (or inactivating) it with a chemical. ❋ Unknown (2008)
Julie has a "[Free Tibet]" sticker on her Subaru. But she hasn't done anything to actually help [free Tibet]. She also has an orange-spotted green ribbon that supports [narcoleptic] dogs. This doesn't do anything for narcoleptic dogs. This is inactivism. ❋ Jamie Perkins (2008)
Nico: Sheee-yit, I installed that [Windoze] security update, and now my web browser is inactivated!
User: [The word's] [deactivated], dummy
Nico: Kiss my ass I get paid triple what you do ❋ Engelbert Humperdinck (2008)
Steven got caught up in Political Inactivism today when he protested [Obamacare] on Facebook for [4 hours] straight and then ate [a ham] sandwich and forgot. ❋ Thesozoguy (2013)
