Integrin

In addition, Merck is developing cilengitide, which is the first in a new class of investigational anti-cancer therapies called integrin inhibitors to reach Phase III of development; it is currently being investigated for the treatment of glioblastoma, SCCHN and NSCLC. ❋ Unknown (2010)

In addition, Merck is developing cilengitide, which is the first in a new class of investigational anti-cancer therapies called integrin inhibitors to reach Phase III of development; it is currently being investigated for the treatment of glioblastoma, ❋ Unknown (2010)

Through their study, they identified a molecule - called LXY1 - that binds with high specificity to a particular cell-surface protein called alpha-3 integrin, which is overexpressed on cancer cells. ❋ Unknown (2009)

Together, these molecules, called integrin and netrin, may be a valuable new target in the efforts to halt cancer's spread via metastasis. ❋ Unknown (2009)

Nature Medicine on 22 March, suggested that such effects might also occur for a class of drugs called integrin inhibitors. ❋ Unknown (2009)

More specifically, they found that release of growth factor by GPR30 required the activation of a latent adhesion receptor (known as integrin 51). ❋ Unknown (2009)

On the other hand, the significance of a complex control of NFAT5 subcellular localization in isotonic conditions might be found outside hypertonic stress responses, since this factor can also regulate osmotic stress-unrelated processes, such as integrin-induced migration, cell differentiation and viral replication The sustained association of NFAT5 with chromatin through mitosis and interphase caused by deletion of its CTD was consistent with the high stability of NFAT5-DNA complexes described previously in vitro ❋ Anaïs Estrada-Gelonch Et Al. (2009)

Likewise, choanoflagellates have five immunoglobulin domains, though they have no immune system; collagen, integrin and cadherin domains, though they have no skeleton or matrix binding cells together; and proteins called tyrosine kinases that are a key part of signaling between cells, even though Monosiga is not known to communicate, or at least does not form colonies. ❋ Unknown (2008)

It can cross-link a number of connective proteins, for example integrin, which allows inflammatory and wound-repair cells to migrate more easily to damaged sites. ❋ Unknown (2007)

Previously the big guns that were hyped to get the blood sugar down were the glitazones now less so and I see invitations coming in for drugs that are attempting to favorably harness the integrin family. ❋ James Gaulte (2007)

Just found this reference showing amoeba have an integrin-like protein (containing an Ig superfold) that is important for phagocytosis, cell adhesion and spreading (but not cell-cell interactions). ❋ Unknown (2006)

Yet, Elan's scientists continue to investigate new small molecule inhibitors that block alpha 4 integrin and may selectively block immune cell traficking. ❋ Unknown (2011)

Alpha 4 integrin has a role in the movement of immune cells from the bloodstream into the tissues in response to inflammation. ❋ Unknown (2011)

However, Welsh et al. used hα5-3T3 cells, stably expressing an α5 human β1 mouse chimeric integrin, and plated the cells on a fibronectin-coated dish. ❋ Shigeyuki Kanazawa Et Al. (2010)

Varner JA (2000) Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A J Biol Chem 275: ❋ Shigeyuki Kanazawa Et Al. (2010)

Rabinovitz I, Wang HH, Toker A, Mercurio AM (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. ❋ Shigeyuki Kanazawa Et Al. (2010)

Therefore, bFGF-integrin cooperation may cause Cdc42 activation in hα5-3T3 cells on fibronectin-coated dishes. ❋ Shigeyuki Kanazawa Et Al. (2010)