Intracoronary

Six weeks ago the Cedars-Sinai Medical Center in Los Angeles began a protocol unique in America, treating patients with intracoronary injections of autologous bone-marrow-derived cells to repair heart-muscle damage caused by a recent heart attack (in the preceding two weeks). ❋ Unknown (2007)

In a second study, presented by Eduardo Marbán at the AHA, 31 patients were randomized on a 2:1 basis to intracoronary infusion of CDCs or a control arm.

In this study, the authorsdid a phase 1 clinical trial of CSCs in patients with heart failure after a heart attack to assess the safety and feasibility of intracoronary CSC infusion, and to test the hypothesis that this intervention would improve the contractile function of the heart and the general clinical status of the patient.

A study of timing, magnitude, reproducibility, and safety of the coronary hyperemic response after intracoronary papaverine. ❋ Rahn Ilsar Et Al. (2010)

Feb. 18/PRNewswire/-- InfraReDx, Inc., an innovative medical device company focused on developing novel diagnostic imaging technologies to accurately identify and characterize diseased intracoronary tissues, today announced that the Company's founder and chief executive officer, James E. Muller, M.D., will present and participate in a number of sessions and panel discussions during the annual Cardiovascular Research Technologies (CRT) 2010 meeting. ❋ Unknown (2010)

InfraReDx's LipiScan system - the only FDA cleared product to detect lipid core plaque - utilizes catheter-based near-infrared (NIR) spectroscopy to identify and assess the composition of intracoronary plaques within artery walls that cannot be detected by commonly used diagnostic tests such as treadmill exams and coronary angiograms. ❋ Unknown (2010)

Left ventricular ejection fraction (LVEF) - the ability of the heart to pump blood from the left ventricle - was 35% or less. 191 of the patients agreed to intracoronary bone marrow stem cell therapy. ❋ Unknown (2010)

Strauer B-E "The STAR Heart Study: the acute and long-term effect of intracoronary stem cell transplantation in 191 patients with chronic heart failure" ESC 2010; Abstract 381. ❋ Unknown (2010)

The results of the study showed improvements in myocardial perfusion (blood flow) in the ischemic region of the hearts of both men and women following a single intracoronary infusion of Generx. ❋ Unknown (2010)

The authors apparently did not have access to data on intracoronary physiologic measurements such as fractional flow reserve (FFR), an important measure of the hemodynamic significance of intermediate ❋ Unknown (2009)

A total of 9 patients with NYHA Class III / IV Heart Failure received a single intracoronary infusion of MYDICAR. ❋ Unknown (2009)

The research also showed that other factors were predictors of CVA, such as the number of diseased coronary arteries, presence of intracoronary thrombus, an increased number of vessels treated and the need for emergency angioplasty. ❋ Unknown (2009)

(perfusion) following a one-time intracoronary administration from a standard cardiac infusion catheter in the heart of patients who have insufficient blood flow due to atherosclerosis plaque build-up in the coronary arteries. ❋ Unknown (2010)

J Am Coll Cardiol 2003; 42: 1339-47) showed that Generx improved myocardial blood flow in the ischemic region of the hearts of men and women following a single intracoronary infusion as measured by the objective efficacy endpoint of SPECT imaging. ❋ Unknown (2010)