Researchers also understood that cancer cells can send out extensions called invadopodia, which release enzymes that dissolve the extracellular matrix (ECM) and clear a path for the cell to move through. ❋ Unknown (2009)
They look remarkably like a structure seen in cancer cells called invadopodia that are believed to have the same function, but modeling this part of metastasis in the lab has proven impossible so far because nobody has figured out how to make a basement membrane in a dish. ❋ Unknown (2009)
Dr. von Bokhoven then began collaborating with Sara A. Courtneidge, Ph. D., at Sanford-Burnham, who had been studying the relationship between TKS4 and invadopodia, cellular protrusions that facilitate cancer cell migration and invasion. ❋ Unknown (2010)
Immunolocalization revealed that HEF1 colocalized to invadopodia with MT1-MMP. ❋ J T Lucas (2010)
Moreover, cells plated on extracellular matrix-coated coverslips showed enhanced invadopodia formation in response to ❋ J T Lucas (2010)
"This research illustrates the importance of collaboration in the scientific discovery process, and how the study of one disease, in this case cancer, can have a profound impact on the understanding on another." said Dr. Courtneidge, "In the future, we hope to use our mouse model to study the disease in more depth, as well as to determine whether other genes involved in invadopodia formation are also associated with FTHS." ❋ Unknown (2010)
These structures then elongate into "mature" invadopodia. ❋ PhysOrg Team (2010)
In the cancer cells, both forms of actin were necessary for invadopodia to form and grow. ❋ PhysOrg Team (2010)
Tumor cells start to dissolve the basement membrane with enzymes that build up within extensions called invadopodia. ❋ PhysOrg Team (2010)
However, microtubules and intermediate filaments were only essential for invadopodia to lengthen. ❋ PhysOrg Team (2010)
The group also observed that in FAK-lacking cells, FAK's helper protein, Src, localized near invadopodia. ❋ Unknown (2009)
Instead, the scientists found that in cells missing FAK, the phosphorylated proteins accumulated in invadopodia. ❋ Unknown (2009)
They report that FAK controls movement by balancing the number of invadopodia that create a path for migration and the number of focal adhesions that hold the cell back. ❋ Unknown (2009)
The current study, published online April 13 in the Journal of Cell Biology, sought to understand whether FAK also regulates invadopodia. ❋ Unknown (2009)
To their surprise, however, the FAK-lacking cells sprouted extra invadopodia. ❋ Unknown (2009)
