NSAIDs, as well as ones sometimes given by IV or injection, such as ketorolac (Toradol). ❋ Unknown (2010)
Just a heads-up .... dolac (ketorolac tromethamine) is for limited, short term use only and can have significant side effects, namely: Stomach upset is the most common, often with nausea, vomiting, bloating, gas, and loss of appetitemay. ❋ Unknown (2006)
However, the ketorolac group scored higher in terms of overall tolerability than the hydrocodone-acetaminophen group. ❋ Ancient (2010)
Following tissue injury, B1 ligands des-Arg9-BK and des-Arg10-KD were significantly lower at the third hour compared to the first 2 hours in both the placebo and the ketorolac treatment groups but did not differ significantly between groups. ❋ May Hamza (2010)
(P = .019); and better total pain relief for ketorolac at 3 hours (P = .014) and 4 hours (P = .013). ❋ Ancient (2010)
Comparison of oral ketorolac and hydrocodone for pain relief after anterior cruciate ligament reconstruction. ❋ Ancient (2010)
If approved, Dyloject will be the first IV non-steroidal anti-inflammatory drug (NSAID) marketed in the United States as a single agent for the management of acute moderate-to-severe pain in adults since ketorolac in 1990. ❋ Unknown (2010)
In a DB study of 125 out-patients with an arthroscopically assisted patellar-tendon autograft anterior cruciate ligament reconstruction, a loading dose of parental ketorolac tromethamine was administered and subjects were later given two staged doses of the same "unknown" drug with pain evaluations conducted after each dose. ❋ Ancient (2010)
Tissue injury also resulted in the down-regulation of TRPV1 gene expression at 3 hours post-surgery with no significant effect by ketorolac treatment. ❋ May Hamza (2010)
In a DB PC study of 207 patients having removal of impacted third molars, a single oral dose of 10 mg of ketorolac resulted in less pain at 3 and 6 hours that 10 mg of hydrocodone plus ❋ Ancient (2010)
In the patients undergoing arthroscopic surgery, both ketorolac and hydromorphone-acetaminophen provided superior pain relief compared with the placebo. ❋ Ancient (2010)
In five out of five double-blind (DB) studies, it was clearly inferior to ketorolac, or celecoxib (Celebrex) even when it had been combined with acetaminophen. ❋ Ancient (2010)
The summed pain intensity difference (SPID), visual analogue scale (VAS) SPID, and total pain relief scores were higher in the ketorolac group compared with the hydrocodone-acetaminophen group, but the differences were not statistically significant. ❋ Ancient (2010)
Interestingly, the up-regulation in the gene expression of B1 and B2 receptors was positively correlated to pain intensity only after ketorolac treatment, signifying an interaction between prostaglandins and kinins in the inflammatory pain process. ❋ May Hamza (2010)
For group 1, dose 1 consisted of ketorolac tromethamine 20 mg orally and dose 2 was ketorolac tromethamine 10 mg. ❋ Ancient (2010)
(P = .02); and lower summed intensity differences for ketorolac at 3 hours (P = .014) and 4 hours ❋ Ancient (2010)
The five most common ones were promethazine, ketorolac, propoxyphene, meperidine, and diphenhydramine; and two of these ❋ Unknown (2010)
Outpatients showed lower categorical pain intensity for ketorolac than hydrocodone/acetaminophen at 1 hour (P = .03), 2 hours (P = .006), and 3 hours ❋ Ancient (2010)
