Kinetochores

Word KINETOCHORES
Character 12
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Kinetochores"

What do we mean by kinetochores?

The protein structure in eukaryotes which assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis.

Synonyms and Antonyms for Kinetochores

  • Synonyms for kinetochores
  • Kinetochores synonyms not found!!!
  • Antonyms for kinetochores
  • Kinetochores antonyms not found!

The word "kinetochores" in example sentences

In the absence of the nuclear membrane, the mitotic spindle microtubules are now free to enter the nuclear region, and formation of specialized protein complexes called kinetochores begins on each centromere.

Meiotic cells (DDO45 and DDO46) were evaluated for the behavior of centromeres by indirect immunofluorescence observation of kinetochores (Mtw1-13XMYC), a pair of homologous centromeres ❋ David Obeso Et Al. (2010)

In 2008, Sarah Thompson and Duane Compton, from Dartmouth Medical School, revealed that most CIN in tumor cells was caused by incorrect attachments between mitotic spindle microtubules and kinetochores, and that inducing misattachments in normal cells was sufficient to generate high rates of chromosome missegregation. ❋ Unknown (2010)

Although meiosis and mitosis share a lot of similarities, numerous differences exist between the spindles in these types of cells and some of these differences have been already identified: (i) centrosomes are present in somatic cells and absent in oocytes; (ii) kinetochores microtubules appear very late in MI ❋ Vincent Gache Et Al. (2010)

During these studies, the scientists noticed that sister kinetochores - the protein structures that mark the site where a chromosome pair is split during cell division - are farther apart in metaphase II eggs from older mice at 16 to 19 months of age compared to eggs from young mice of 6 to 14 weeks of age, a finding that drew their attention to explore reduced cohesion as a primary source for age-related aneuploidy. ❋ Unknown (2010)

According to the published evidence, the above proteins or their previously characterized orthologs from other species localized to interphase and/or spindle microtubules, kinetochores, midbody and the centrosome. ❋ Vincent Gache Et Al. (2010)

In addition, we investigate the assembly, dynamics and function of the mitotic structures such as the mitotic spindle, kinetochores and the cleavage furrow by using a combination of genetics, biochemistry, cell biology, and chemical genetics, and our long-term goal is to elucidate the molecular and cellular basis of cell division as well as to provide novel targets for chemotherapy. ❋ Unknown (2010)

Our data indicate that Nup107-160 and γ-TuRC act cooperatively to promote spindle assembly through microtubule nucleation at kinetochores: HeLa cells lacking Nup107-160 or γ-TuRC were profoundly deficient in kinetochore-associated microtubule nucleation. ❋ Ram Kumar Mishra (2010)

The unattached kinetochores nucleate microtubules in a manner that is regulated by Ran GTPase ❋ Ram Kumar Mishra (2010)

We deliberately refrained from merging the identified proteins into complexes specific for the kinetochores and the centrosome, since we found in our screen only a limited number of proteins related to these structures. ❋ Vincent Gache Et Al. (2010)

The metazoan nuclear pore complex (NPC) disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 sub-complex. ❋ Ram Kumar Mishra (2010)

We propose that such networks may further evolve to describe not only MeMP, but also the mitotic spindle of metazoan organisms with its much more complex apparatus, including kinetochores, centrosomes and chromosomes. ❋ Vincent Gache Et Al. (2010)

Collectively, our observations show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by γ-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. ❋ Ram Kumar Mishra (2010)

(SAC), whose components localize at kinetochores, function as a "proofreading network" by creating a diffusible signal indispensable to delay anaphase progression thus ensuring the prevention of aberrant mitosis. ❋ Unknown (2009)

The tetrads also connect to the spindle fibers through kinetochores. ❋ Unknown (2009)

The tetrads arrange across the center by movements of the kinetochores. ❋ Unknown (2009)

Cross Reference for Kinetochores

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What does kinetochores mean?

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