In fact, the recruitment of similar resistance determinants within a single P. aeruginosa strain can determine a resistance phenotype to virtually all the available antipseudomonal beta-lactams, an occurrence that can be particularly dramatic when, as in the present case, resistance to beta-lactams is associated with resistance against aminoglycosides and fluoroquinolones. link (emphasis mine) ❋ Unknown (2008)
PFGE, the molecular-fingerprint technique, had not been invented yet,14 but the MRSA strains in the addicts and in the Henry Ford patients were resistant to exactly the same medications: methicillin and all the beta- lactams, and two additional classes of drugs. ❋ MARYN MCKENNA (2010)
In Pseudomonas aeruginosa, secondary beta-lactamases with extended substrate specificity can be responsible for acquired resistance to the most powerful antipseudomonal beta-lactams, such as expanded-spectrum cephalosporins and carbapenems. ❋ Unknown (2008)
The strain must have been in pigs for a while, because in addition to methicillin and the rest of the beta–lactams, it was also resistant to tetracycline. ❋ MARYN MCKENNA (2010)
Even with related substrates, some showed big changes others little, so without a good panel of beta-lactams to check the function of the crippled enzyme, the functional space represented is under sampled. ❋ Unknown (2007)
Antibiotics such as penicillin are called, collectively, beta-lactams, and enzymes that break down these antibiotics and confer drug resistance are called beta-lactamases, which is why the term beta-lactamase may pop up in this blog entry from time to time. ❋ Unknown (2007)
MRSA is by definition a strain of Staphylococcus aureus that is resistant to a large group of antibiotics called the beta-lactams, which include the penicillins and the cephalosporins. ❋ Unknown (2010)
DSM's production infrastructure for fermentation and associated product recovery and purification is based in a multipurpose facility in Capua, Italy, which currently produces pharmaceutical intermediates and APIs (with the exception of beta-lactams) and food/nutrition-related products. ❋ Unknown (2010)
Blanchard, a professor at Albert Einstein's department of biochemistry, and his team have specifically targeted an enzyme called beta-lactamase, which can break down and disable beta-lactams, a large family of antibiotics that includes penicillin and its relatives. ❋ Unknown (2010)
"When the M. tuberculosis genome was sequenced a few years ago, the presence of this beta-lactamase enzyme was discovered," Blanchard says, "which was surprising since beta-lactams have never been systematically used to treat TB." ❋ Unknown (2010)
Greater sales of test kits with higher average selling prices, and ongoing growth in sales of Neogen's new BetaStar Combo test, that detects both beta-lactams and tetracycline were the primary reasons for this growth. ❋ Unknown (2010)
Shigeta M, Komatsuzawa H, Sugai M, Suginaka H, et al. (1999) Effect of the growth rate of Pseudomonas aeruginosa biofilms on the susceptibility to antimicrobial agents: beta-lactams and fluoroquinolones. ❋ Chakrit Sawasdidoln Et Al. (2010)
The researchers based the new treatment on growing evidence that beta-lactams are relatively ineffective against secondary pneumonia because the drugs exacerbate inflammation caused by influenza.
And, treatment with beta-lactams releases bacterial components into the bloodstream that the immune system recognizes, triggering an inflammatory burst that can be deadly.
"The current guidelines still adhere to the theory that beta-lactams are the only drugs of choice, because it is necessary to kill the bacteria as fast as possible," he said.
