Lamellipodial

Fig. 2C, the bFGF-treated fibroblasts significantly developed lamellipodial extension in the scratch wound. ❋ Shigeyuki Kanazawa Et Al. (2010)

This lamellipodial extension provides the driving force for the protrusive activity required for cell migration ❋ Shigeyuki Kanazawa Et Al. (2010)

The bFGF-treated fibroblasts developed lamellipodial extension (arrowhead). ❋ Shigeyuki Kanazawa Et Al. (2010)

Rac1 induces the formation of lamellipodial protrusions via activation of the Wave complex ❋ Shigeyuki Kanazawa Et Al. (2010)

Therefore, our data suggest that bFGF induced lamellipodial extension of the fibroblasts and promoted migration. ❋ Shigeyuki Kanazawa Et Al. (2010)

In our study, the bFGF-treated fibroblasts showed more lamellipodial extension at 1 h after wounding as compared to the control cells. ❋ Shigeyuki Kanazawa Et Al. (2010)

Lamellipodial extension was quantified by summing the length of the outer margins of all lamellipodium in individual cells, and was expressed as a proportion of the total perimeter of each cell (lamellipodial index), as described by Verma et al. [24]. bFGF induced lamellipodial extension at 1 h ❋ Shigeyuki Kanazawa Et Al. (2010)

** P doi: 10.1371/journal. pone.0012228.g001 bFGF promoted fibroblast migration and induced lamellipodial extension ❋ Shigeyuki Kanazawa Et Al. (2010)

Activation of PI3-kinase leads to up-regulation of Rac1, followed by the activation of JNK, resulting in formation of lamellipodial extension. ❋ Shigeyuki Kanazawa Et Al. (2010)

Hu H, Kim YH, Beggs HE, Reichardt LF, et al. (2006) Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. ❋ Ruchika Srinivasan Et Al. (2009)

a proportion of the total perimeter for each cell (lamellipodial index). ❋ Shigeyuki Kanazawa Et Al. (2010)

Moreover, immunocytochemistry showed that the bFGF-treated fibroblasts developed lamellipodial extension after wounding ( ❋ Shigeyuki Kanazawa Et Al. (2010)

Those cells at 6 h after wounding showed more lamellipodial extension and increased migration speed ( ❋ Shigeyuki Kanazawa Et Al. (2010)